Sequence Detail

ID/Version

P20917 P16880 A0A087WPR1 (UniProt | EBI)

Last sequence update: 2019-09-18
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Myelin-associated glycoprotein;AltName: Full=Siglec-4a;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 627 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Mag	myelin-associated glycoprotein	73	107	3	10

Sequence references in MGI

J:10215 Fujita N, et al., cDNA cloning of mouse myelin-associated glycoprotein: a novel alternative splicing pattern. Biochem Biophys Res Commun. 1989 Dec 29;165(3):1162-9
J:11313 Nakano R, et al., Structure of mouse myelin-associated glycoprotein gene. Biochem Biophys Res Commun. 1991 Jul 15;178(1):282-90
J:18407 Li C, et al., Myelination in the absence of myelin-associated glycoprotein. Nature. 1994 Jun 30;369(6483):747-50
J:41802 Bartsch S, et al., Increased number of unmyelinated axons in optic nerves of adult mice deficient in the myelin-associated glycoprotein (MAG). Brain Res. 1997 Jul 11;762(1-2):231-4
J:45616 Li C, et al., Myelin associated glycoprotein modulates glia-axon contact in vivo. J Neurosci Res. 1998 Jan 15;51(2):210-7
J:46770 Fujita N, et al., The cytoplasmic domain of the large myelin-associated glycoprotein isoform is needed for proper CNS but not peripheral nervous system myelination. J Neurosci. 1998 Mar 15;18(6):1970-8
J:60058 Schachner M, et al., Multiple functions of the myelin-associated glycoprotein MAG (siglec-4a) in formation and maintenance of myelin. Glia. 2000 Jan 15;29(2):154-65
J:100940 Pan B, et al., Myelin-associated glycoprotein and complementary axonal ligands, gangliosides, mediate axon stability in the CNS and PNS: neuropathology and behavioral deficits in single- and double-null mice. Exp Neurol. 2005 Sep;195(1):208-17
J:125387 Mehta NR, et al., Gangliosides and Nogo receptors independently mediate myelin-associated glycoprotein inhibition of neurite outgrowth in different nerve cells. J Biol Chem. 2007 Sep 21;282(38):27875-86
J:144847 Nguyen T, et al., Axonal protective effects of the myelin-associated glycoprotein. J Neurosci. 2009 Jan 21;29(3):630-7
J:160879 Yin X, et al., Myelin-associated glycoprotein is a myelin signal that modulates the caliber of myelinated axons. J Neurosci. 1998 Mar 15;18(6):1953-62
J:202979 Shin D, et al., Very large G protein-coupled receptor 1 regulates myelin-associated glycoprotein via Galphas/Galphaq-mediated protein kinases A/C. Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):19101-6
J:230364 Liu BP, et al., Myelin-associated glycoprotein as a functional ligand for the Nogo-66 receptor. Science. 2002 Aug 16;297(5584):1190-3
J:238442 Palandri A, et al., Myelin-associated glycoprotein modulates apoptosis of motoneurons during early postnatal development via NgR/p75(NTR) receptor-mediated activation of RhoA signaling pathways. Cell Death Dis. 2015 Sep 03;6:e1876
J:238475 Pronker MF, et al., Structural basis of myelin-associated glycoprotein adhesion and signalling. Nat Commun. 2016 Dec 06;7:13584
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89