Sequence Detail

ID/Version

P20444 (UniProt | EBI)

Last sequence update: 2007-01-23
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Protein kinase C alpha type; Short=PKC-A; Short=PKC-alpha; EC=2.7.11.13 {ECO:0000250|UniProtKB:P17252};

Provider

SWISS-PROT

Sequence

Polypeptide 672 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Prkca	protein kinase C, alpha	149	139	4	17

Sequence references in MGI

J:9748 Rose-John S, et al., Molecular cloning of mouse protein kinase C (PKC) cDNA from Swiss 3T3 fibroblasts. Gene. 1988 Dec 30;74(2):465-71
J:41185 Staudinger J, et al., PICK1: a perinuclear binding protein and substrate for protein kinase C isolated by the yeast two-hybrid system. J Cell Biol. 1995 Feb;128(3):263-71
J:41343 Megidish T, et al., A mutant protein kinase C that can transform fibroblasts. Nature. 1989 Dec 14;342(6251):807-11
J:84787 Kawakami Y, et al., A Ras activation pathway dependent on Syk phosphorylation of protein kinase C. Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9470-5
J:137601 Ikenoue T, et al., Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling. EMBO J. 2008 Jul 23;27(14):1919-31
J:145973 Konopatskaya O, et al., PKCalpha regulates platelet granule secretion and thrombus formation in mice. J Clin Invest. 2009 Feb;119(2):399-407
J:156998 Robles MS, et al., Identification of RACK1 and protein kinase Calpha as integral components of the mammalian circadian clock. Science. 2010 Jan 22;327(5964):463-6
J:180500 Pierce A, et al., An activated protein kinase C alpha gives a differentiation signal for hematopoietic progenitor cells and mimicks macrophage colony-stimulating factor-stimulated signaling events. J Cell Biol. 1998 Mar 23;140(6):1511-8
J:280563 Lear TB, et al., KIAA0317 regulates pulmonary inflammation through SOCS2 degradation. JCI Insight. 2019 Oct 3;4(19)
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:355636 Baffi TR, et al., mTORC2 controls the activity of PKC and Akt by phosphorylating a conserved TOR interaction motif. Sci Signal. 2021 Apr 13;14(678)