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Sequence Detail
ID/Version
P15392 Q91XG2 (UniProt | EBI) Last sequence update: 2012-10-03
Last annotation update: 2019-12-11
Sequence
description
from provider
RecName: Full=Cytochrome P450 2A4; EC=1.14.14.1;AltName: Full=CYPIIA4;AltName: Full=Cytochrome P450-15-alpha;AltName: Full=Cytochrome P450-IIA3.1;AltName: Full=Testosterone 15-alpha-hydroxylase;
Provider SWISS-PROT
Sequence
Polypeptide 494 aa
For this sequence
Source
Organism mouse
See UniProt | EBI for source
Annotated genes and markers Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.
Type Symbol Name GO Terms Expression
Assays
Orthologs Phenotypic
Alleles
Gene Cyp2a4 cytochrome P450, family 2, subfamily a, polypeptide 4 17 3 12 2
Sequence references in MGI J:30925 Lindberg RL, et al., Alteration of mouse cytochrome P450coh substrate specificity by mutation of a single amino-acid residue. Nature. 1989 Jun 22;339(6226):632-4
J:30944 Squires EJ, et al., Reciprocal regulation of sex-dependent expression of testosterone 15 alpha-hydroxylase (P-450(15 alpha)) in liver and kidney of male mice by androgen. Evidence for a single gene. J Biol Chem. 1988 Mar 25;263(9):4166-71
J:37044 Lindberg R, et al., The structure and characterization of type I P-450(15) alpha gene as major steroid 15 alpha-hydroxylase and its comparison with type II P-450(15) alpha gene. J Biol Chem. 1989 Apr 15;264(11):6465-71
J:120430 Lavery DJ, et al., Circadian expression of the steroid 15 alpha-hydroxylase (Cyp2a4) and coumarin 7-hydroxylase (Cyp2a5) genes in mouse liver is regulated by the PAR leucine zipper transcription factor DBP. Mol Cell Biol. 1999 Oct;19(10):6488-99

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/07/2020
MGI 6.14
The Jackson Laboratory