Sequence Detail

ID/Version

P12813 (UniProt | EBI)

Last sequence update: 1989-10-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Nuclear receptor subfamily 4 group A member 1;AltName: Full=Nuclear hormone receptor NUR/77;AltName: Full=Nuclear protein N10;AltName: Full=Orphan nuclear receptor HMR;

Provider

SWISS-PROT

Sequence

Polypeptide 601 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Nr4a1	nuclear receptor subfamily 4, group A, member 1	106	119	3	25

Sequence references in MGI

J:9459 Hazel TG, et al., A gene inducible by serum growth factors encodes a member of the steroid and thyroid hormone receptor superfamily. Proc Natl Acad Sci U S A. 1988 Nov;85(22):8444-8
J:10103 Ryseck RP, et al., Structure, mapping and expression of a growth factor inducible gene encoding a putative nuclear hormonal binding receptor. EMBO J. 1989 Nov;8(11):3327-35
J:212520 Papac-Milicevic N, et al., The interferon stimulated gene 12 inactivates vasculoprotective functions of NR4A nuclear receptors. Circ Res. 2012 Apr 13;110(8):e50-63
J:270740 Koenis DS, et al., Nuclear Receptor Nur77 Limits the Macrophage Inflammatory Response through Transcriptional Reprogramming of Mitochondrial Metabolism. Cell Rep. 2018 Aug 21;24(8):2127-2140.e7
J:334741 Zhu F, et al., The orphan receptor Nur77 binds cytoplasmic LPS to activate the non-canonical NLRP3 inflammasome. Immunity. 2023 Apr 11;56(4):753-767.e8