Sequence Detail

ID/Version

P11378 Q91XK4 (UniProt | EBI)

Last sequence update: 2017-06-07
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=Nuclear transition protein 2; Short=TP-2; Short=TP2;

Provider

SWISS-PROT

Sequence

Polypeptide 117 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Tnp2	transition protein 2	23	101	2	3

Sequence references in MGI

J:8975 Kleene KC, et al., Characterization of a cDNA clone encoding a basic protein, TP2, involved in chromatin condensation during spermiogenesis in the mouse. J Biol Chem. 1987 Dec 25;262(36):17272-7
J:10855 Kleene KC, et al., Nucleotide sequence of the gene encoding mouse transition protein 2. Gene. 1990 Nov 15;95(2):301-2
J:30554 Schluter G, et al., Sequence analysis of the conserved protamine gene cluster shows that it contains a fourth expressed gene. Mol Reprod Dev. 1996 Jan;43(1):1-6
J:89779 Zhao M, et al., Transition nuclear proteins are required for normal chromatin condensation and functional sperm development. Genesis. 2004 Apr;38(4):200-13
J:93181 Shirley CR, et al., Abnormalities and reduced reproductive potential of sperm from Tnp1- and Tnp2-null double mutant mice. Biol Reprod. 2004 Oct;71(4):1220-9
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:107120 Zhao M, et al., Nucleoprotein transitions during spermiogenesis in mice with transition nuclear protein Tnp1 and Tnp2 mutations. Biol Reprod. 2004 Sep;71(3):1016-25
J:241000 Barral S, et al., Histone Variant H2A.L.2 Guides Transition Protein-Dependent Protamine Assembly in Male Germ Cells. Mol Cell. 2017 Apr 06;66(1):89-101.e8