Sequence Detail

ID/Version

P06537 E9PYV1 Q61628 Q61629 Q3U126 E0ZPU5 E9PUR6 Q06VW2 Q3U2M7 (UniProt | EBI)

Last sequence update: 2021-09-29
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Glucocorticoid receptor; Short=GR;AltName: Full=Nuclear receptor subfamily 3 group C member 1;

Provider

SWISS-PROT

Sequence

Polypeptide 792 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Nr3c1	nuclear receptor subfamily 3, group C, member 1	177	144	3	31

Sequence references in MGI

J:8476 Danielsen M, et al., The mouse glucocorticoid receptor: mapping of functional domains by cloning, sequencing and expression of wild-type and mutant receptor proteins. EMBO J. 1986 Oct;5(10):2513-22
J:15362 Nohno T, et al., Novel cDNA sequence possibly generated by alternative splicing of a mouse glucocorticoid receptor gene transcript from Shionogi carcinoma 115. Nucleic Acids Res. 1989 Jan 11;17(1):445
J:60637 McNally JG, et al., The glucocorticoid receptor: rapid exchange with regulatory sites in living cells. Science. 2000 Feb 18;287(5456):1262-5
J:74637 Davies TH, et al., A new first step in activation of steroid receptors: hormone-induced switching of FKBP51 and FKBP52 immunophilins. J Biol Chem. 2002 Feb 15;277(7):4597-600
J:89011 Tronche F, et al., Glucocorticoid receptor function in hepatocytes is essential to promote postnatal body growth. Genes Dev. 2004 Mar 1;18(5):492-7
J:97484 Brewer JA, et al., T-cell glucocorticoid receptor is required to suppress COX-2-mediated lethal immune activation. Nat Med. 2003 Oct;9(10):1318-22
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:114395 Xu D, et al., A polymorphic glucocorticoid receptor in a mouse population may explain inherited altered stress response and increased anxiety-type behaviors. FASEB J. 2006 Nov;20(13):2414-6
J:178732 Hinds TD Jr, et al., Protein Phosphatase 5 Mediates Lipid Metabolism through Reciprocal Control of Glucocorticoid Receptor and Peroxisome Proliferator-activated Receptor-gamma (PPARgamma). J Biol Chem. 2011 Dec 16;286(50):42911-22
J:179376 Lamia KA, et al., Cryptochromes mediate rhythmic repression of the glucocorticoid receptor. Nature. 2011 Dec 22;480(7378):552-6
J:182845 Hinds TD Jr, et al., Discovery of glucocorticoid receptor-beta in mice with a role in metabolism. Mol Endocrinol. 2010 Sep;24(9):1715-27
J:209571 Goriki A, et al., A novel protein, CHRONO, functions as a core component of the mammalian circadian clock. PLoS Biol. 2014 Apr;12(4):e1001839
J:244975 Kriebs A, et al., Circadian repressors CRY1 and CRY2 broadly interact with nuclear receptors and modulate transcriptional activity. Proc Natl Acad Sci U S A. 2017 Aug 15;114(33):8776-8781
J:247279 Okabe T, et al., REV-ERBalpha influences the stability and nuclear localization of the glucocorticoid receptor. J Cell Sci. 2016 Nov 01;129(21):4143-4154
J:273438 Magomedova L, et al., ARGLU1 is a transcriptional coactivator and splicing regulator important for stress hormone signaling and development. Nucleic Acids Res. 2019 Apr 8;47(6):2856-2870
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:306378 Guo A, et al., Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. Mol Cell Proteomics. 2014 Jan;13(1):372-87