Sequence Detail

ID/Version

O89026 (UniProt | EBI)

Last sequence update: 1998-11-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Roundabout homolog 1;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 1612 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Robo1	roundabout guidance receptor 1	67	157	3	25

Sequence references in MGI

J:47685 Sundaresan V, et al., The DUTT1 gene, a novel NCAM family member is expressed in developing murine neural tissues and has an unusually broad pattern of expression. Mol Cell Neurosci. 1998 May;11(1-2):29-35
J:56938 Yuan W, et al., The mouse SLIT family: secreted ligands for ROBO expressed in patterns that suggest a role in morphogenesis and axon guidance. Dev Biol. 1999 Aug 15;212(2):290-306
J:73485 Xian J, et al., Inadequate lung development and bronchial hyperplasia in mice with a targeted deletion in the Dutt1/Robo1 gene. Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):15062-6
J:78151 Clark K, et al., Temporal and spatial expression of two isoforms of the Dutt1/Robo1 gene in mouse development. FEBS Lett. 2002 Jul 17;523(1-3):12-6
J:89780 Long H, et al., Conserved roles for Slit and Robo proteins in midline commissural axon guidance. Neuron. 2004 Apr 22;42(2):213-23
J:153134 Yuasa-Kawada J, et al., Midline crossing and Slit responsiveness of commissural axons require USP33. Nat Neurosci. 2009 Sep;12(9):1087-9
J:156034 Yuasa-Kawada J, et al., Deubiquitinating enzyme USP33/VDU1 is required for Slit signaling in inhibiting breast cancer cell migration. Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14530-5
J:224719 Leyva-Diaz E, et al., FLRT3 is a Robo1-interacting protein that determines Netrin-1 attraction in developing axons. Curr Biol. 2014 Mar 3;24(5):494-508
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89