Sequence Detail

ID/Version

O88643 (UniProt | EBI)

Last sequence update: 1998-11-01
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Serine/threonine-protein kinase PAK 1 {ECO:0000305}; EC=2.7.11.1 {ECO:0000250|UniProtKB:Q13153};AltName: Full=Alpha-PAK {ECO:0000250|UniProtKB:Q13153};AltName: Full=CDC42/RAC effector kinase PAK-A;AltName: Full=p21-activated kinase 1

Provider

SWISS-PROT

Sequence

Polypeptide 545 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Pak1	p21 (RAC1) activated kinase 1	140	131	3	71

Sequence references in MGI

J:55429 Burbelo PD, et al., Cloning, central nervous system expression and chromosomal mapping of the mouse PAK-1 and PAK-3 genes. Gene. 1999 May 31;232(2):209-15
J:78399 Luo ZG, et al., Regulation of AChR clustering by Dishevelled interacting with MuSK and PAK1. Neuron. 2002 Aug 1;35(3):489-505
J:93054 Alahari SK, et al., The integrin-binding protein Nischarin regulates cell migration by inhibiting PAK. EMBO J. 2004 Jul 21;23(14):2777-88
J:98630 Zhang H, et al., A GIT1/PIX/Rac/PAK signaling module regulates spine morphogenesis and synapse formation through MLC. J Neurosci. 2005 Mar 30;25(13):3379-88
J:140161 Nola S, et al., Scrib regulates PAK activity during the cell migration process. Hum Mol Genet. 2008 Nov 15;17(22):3552-65
J:188803 Ijuin T, et al., Regulation of insulin signaling by the phosphatidylinositol 3,4,5-triphosphate phosphatase SKIP through the scaffolding function of Pak1. Mol Cell Biol. 2012 Sep;32(17):3570-84
J:188847 Nie J, et al., Synapses of amphids defective (SAD-A) kinase promotes glucose-stimulated insulin secretion through activation of p21-activated kinase (PAK1) in pancreatic beta-Cells. J Biol Chem. 2012 Jul 27;287(31):26435-44
J:269564 Purohit AA, et al., Down syndrome cell adhesion molecule (DSCAM) associates with uncoordinated-5C (UNC5C) in netrin-1-mediated growth cone collapse. J Biol Chem. 2012 Aug 3;287(32):27126-38
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89