Sequence Detail

ID/Version

O88522 Q924H4 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=NF-kappa-B essential modulator; Short=NEMO;AltName: Full=IkB kinase-associated protein 1; Short=IKKAP1; Short=mFIP-3;AltName: Full=Inhibitor of nuclear factor kappa-B kinase subunit gamma; Short=I-kappa-B kina

Provider

SWISS-PROT

Sequence

Polypeptide 412 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ikbkg	inhibitor of kappaB kinase gamma	102	99	3	19

Sequence references in MGI

J:48478 Yamaoka S, et al., Complementation cloning of NEMO, a component of the IkappaB kinase complex essential for NF-kappaB activation. Cell. 1998 Jun 26;93(7):1231-40
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:120483 Prajapati S, et al., Regulation of Ikappa B kinase (IKK)gamma /NEMO function by IKKbeta -mediated phosphorylation. J Biol Chem. 2002 Jul 5;277(27):24331-9
J:163158 Teo H, et al., Telomere-independent Rap1 is an IKK adaptor and regulates NF-kappaB-dependent gene expression. Nat Cell Biol. 2010 Aug;12(8):758-67
J:281166 Zhang X, et al., Ubiquitination of RIPK1 suppresses programmed cell death by regulating RIPK1 kinase activation during embryogenesis. Nat Commun. 2019 Sep 13;10(1):4158
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:297482 Chathuranga K, et al., Negative regulation of NEMO signaling by the ubiquitin E3 ligase MARCH2. EMBO J. 2020 Nov 2;39(21):e105139