Sequence Detail

ID/Version

O55091 Q9EQH0 Q3UUR6 (UniProt | EBI)

Last sequence update: 1999-01-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Protein IMPACT;AltName: Full=Imprinted and ancient gene protein;

Provider

SWISS-PROT

Sequence

Polypeptide 318 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Impact	impact, RWD domain protein	25	105	3	17

Sequence references in MGI

J:42447 Hagiwara Y, et al., Screening for imprinted genes by allelic message display: identification of a paternally expressed gene impact on mouse chromosome 18. Proc Natl Acad Sci U S A. 1997 Aug 19;94(17):9249-54
J:66231 Okamura K, et al., Comparative genome analysis of the mouse imprinted gene impact and its nonimprinted human homolog IMPACT: toward the structural basis for species-specific imprinting. Genome Res. 2000 Dec;10(12):1878-89
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:100824 Pereira CM, et al., IMPACT, a protein preferentially expressed in the mouse brain, binds GCN1 and inhibits GCN2 activation. J Biol Chem. 2005 Aug 5;280(31):28316-23
J:197824 Roffe M, et al., IMPACT is a developmentally regulated protein in neurons that opposes the eukaryotic initiation factor 2alpha kinase GCN2 in the modulation of neurite outgrowth. J Biol Chem. 2013 Apr 12;288(15):10860-9
J:211861 Cambiaghi TD, et al., Evolutionarily conserved IMPACT impairs various stress responses that require GCN1 for activating the eIF2 kinase GCN2. Biochem Biophys Res Commun. 2014 Jan 10;443(2):592-7
J:227376 Waller T, et al., Evidence that Yih1 resides in a complex with ribosomes. FEBS J. 2012 May;279(10):1761-76
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89