Sequence Detail

ID/Version

O54967 Q0Z844 Q8K0K4 Q8C2U0 (UniProt | EBI)

Last sequence update: 2007-12-04
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Activated CDC42 kinase 1; Short=ACK-1; EC=2.7.10.2; EC=2.7.11.1;AltName: Full=Non-receptor protein tyrosine kinase Ack;AltName: Full=Tyrosine kinase non-receptor protein 2;

Provider

SWISS-PROT

Sequence

Polypeptide 1055 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Tnk2	tyrosine kinase, non-receptor, 2	55	109	4	36

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:100995 Urena JM, et al., Expression, synaptic localization, and developmental regulation of Ack1/Pyk1, a cytoplasmic tyrosine kinase highly expressed in the developing and adult brain. J Comp Neurol. 2005 Sep 19;490(2):119-32
J:111029 Galisteo ML, et al., Activation of the nonreceptor protein tyrosine kinase Ack by multiple extracellular stimuli. Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):9796-801
J:112339 La Torre A, et al., Expression pattern of ACK1 tyrosine kinase during brain development in the mouse. Gene Expr Patterns. 2006 Oct 2;6(8):886-892
J:123889 Shen F, et al., Activated Cdc42-associated kinase 1 is a component of EGF receptor signaling complex and regulates EGF receptor degradation. Mol Biol Cell. 2007 Mar;18(3):732-42
J:158889 Mahajan K, et al., Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation. PLoS One. 2010;5(3):e9646
J:170793 Lin Q, et al., HECT E3 ubiquitin ligase Nedd4-1 ubiquitinates ACK and regulates epidermal growth factor (EGF)-induced degradation of EGF receptor and ACK. Mol Cell Biol. 2010 Mar;30(6):1541-54
J:182890 Shen H, et al., Constitutive activated Cdc42-associated kinase (Ack) phosphorylation at arrested endocytic clathrin-coated pits of cells that lack dynamin. Mol Biol Cell. 2011 Feb 15;22(4):493-502
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:306378 Guo A, et al., Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. Mol Cell Proteomics. 2014 Jan;13(1):372-87