Sequence Detail

ID/Version

O54943 O54954 (UniProt | EBI)

Last sequence update: 1999-07-15 Last annotation update: 2013-05-01

Sequence description from provider

RecName: Full=Period circadian protein homolog 2; Short=mPER2;AltName: Full=Circadian clock protein PERIOD 2;

Provider

SWISS-PROT

Sequence

Polypeptide 1257 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Per2	period circadian clock 2	19	14	5	9

Sequence references in MGI

J:44820 Albrecht U, et al., A differential response of two putative mammalian circadian regulators, mper1 and mper2, to light. Cell. 1997 Dec 26;91(7):1055-64
J:45182 Shearman LP, et al., Two period homologs: circadian expression and photic regulation in the suprachiasmatic nuclei. Neuron. 1997 Dec;19(6):1261-9
J:51392 Sangoram AM, et al., Mammalian circadian autoregulatory loop: a timeless ortholog and mPer1 interact and negatively regulate CLOCK-BMAL1-induced transcription. Neuron. 1998 Nov;21(5):1101-13
J:73173 Vielhaber EL, et al., Nuclear Export of Mammalian PERIOD Proteins. J Biol Chem. 2001 Dec 7;276(49):45921-7
J:87576 Lee C, et al., Direct association between mouse PERIOD and CKIepsilon is critical for a functioning circadian clock. Mol Cell Biol. 2004 Jan;24(2):584-94
J:106987 Chaves I, et al., Functional evolution of the photolyase/cryptochrome protein family: importance of the C terminus of mammalian CRY1 for circadian core oscillator performance. Mol Cell Biol. 2006 Mar;26(5):1743-53
J:120341 Ohno T, et al., The negative transcription factor E4BP4 is associated with circadian clock protein PERIOD2. Biochem Biophys Res Commun. 2007 Mar 23;354(4):1010-5
J:150148 Etchegaray JP, et al., Casein kinase 1 delta regulates the pace of the mammalian circadian clock. Mol Cell Biol. 2009 Jul;29(14):3853-66
J:150484 Hennig S, et al., Structural and functional analyses of PAS domain interactions of the clock proteins Drosophila PERIOD and mouse PERIOD2. PLoS Biol. 2009 Apr 28;7(4):e94
J:177241 Ozber N, et al., Identification of two amino acids in the C-terminal domain of mouse CRY2 essential for PER2 interaction. BMC Mol Biol. 2010;11:69
J:181918 Miki T, et al., PML regulates PER2 nuclear localization and circadian function. EMBO J. 2012;31(6):1427-39