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Sequence Detail
O54943 O54954 (UniProt | EBI) Last sequence update: 1999-07-15
Last annotation update: 2016-06-08
from provider
RecName: Full=Period circadian protein homolog 2; Short=mPER2;AltName: Full=Circadian clock protein PERIOD 2;
Polypeptide 1257 aa
For this sequence
Organism mouse
See UniProt | EBI for source
Sequence references in MGI J:44820 Albrecht U, et al., A differential response of two putative mammalian circadian regulators, mper1 and mper2, to light. Cell. 1997 Dec 26;91(7):1055-64
J:45182 Shearman LP, et al., Two period homologs: circadian expression and photic regulation in the suprachiasmatic nuclei. Neuron. 1997 Dec;19(6):1261-9
J:51392 Sangoram AM, et al., Mammalian circadian autoregulatory loop: a timeless ortholog and mPer1 interact and negatively regulate CLOCK-BMAL1-induced transcription. Neuron. 1998 Nov;21(5):1101-13
J:69626 Bae K, et al., Differential Functions of mPer1, mPer2, and mPer3 in the SCN Circadian Clock. Neuron. 2001 May;30(2):525-36
J:73173 Vielhaber EL, et al., Nuclear Export of Mammalian PERIOD Proteins. J Biol Chem. 2001 Dec 7;276(49):45921-7
J:87576 Lee C, et al., Direct association between mouse PERIOD and CKIepsilon is critical for a functioning circadian clock. Mol Cell Biol. 2004 Jan;24(2):584-94
J:106987 Chaves I, et al., Functional evolution of the photolyase/cryptochrome protein family: importance of the C terminus of mammalian CRY1 for circadian core oscillator performance. Mol Cell Biol. 2006 Mar;26(5):1743-53
J:113744 Yelamanchili SV, et al., Differential sorting of the vesicular glutamate transporter 1 into a defined vesicular pool is regulated by light signaling involving the clock gene Period2. J Biol Chem. 2006 Jun 9;281(23):15671-9
J:116444 Etchegaray JP, et al., The polycomb group protein EZH2 is required for mammalian circadian clock function. J Biol Chem. 2006 Jul 28;281(30):21209-15
J:120341 Ohno T, et al., The negative transcription factor E4BP4 is associated with circadian clock protein PERIOD2. Biochem Biophys Res Commun. 2007 Mar 23;354(4):1010-5
J:135908 Viswambharan H, et al., Mutation of the circadian clock gene Per2 alters vascular endothelial function. Circulation. 2007 Apr 24;115(16):2188-95
J:139296 Asher G, et al., SIRT1 regulates circadian clock gene expression through PER2 deacetylation. Cell. 2008 Jul 25;134(2):317-28
J:150148 Etchegaray JP, et al., Casein kinase 1 delta regulates the pace of the mammalian circadian clock. Mol Cell Biol. 2009 Jul;29(14):3853-66
J:150484 Hennig S, et al., Structural and functional analyses of PAS domain interactions of the clock proteins Drosophila PERIOD and mouse PERIOD2. PLoS Biol. 2009 Apr 28;7(4):e94
J:154857 Chen R, et al., Rhythmic PER abundance defines a critical nodal point for negative feedback within the circadian clock mechanism. Mol Cell. 2009 Nov 13;36(3):417-30
J:154880 Sasaki M, et al., Preferential inhibition of BMAL2-CLOCK activity by PER2 reemphasizes its negative role and a positive role of BMAL2 in the circadian transcription. J Biol Chem. 2009 Sep 11;284(37):25149-59
J:156994 Schmutz I, et al., The mammalian clock component PERIOD2 coordinates circadian output by interaction with nuclear receptors. Genes Dev. 2010 Feb 15;24(4):345-57
J:166433 Ohsaki K, et al., The role of {beta}-TrCP1 and {beta}-TrCP2 in circadian rhythm generation by mediating degradation of clock protein PER2. J Biochem. 2008 Nov;144(5):609-18
J:167907 Grimaldi B, et al., PER2 controls lipid metabolism by direct regulation of PPARgamma. Cell Metab. 2010 Nov 3;12(5):509-20
J:173532 Duong HA, et al., A molecular mechanism for circadian clock negative feedback. Science. 2011 Jun 17;332(6036):1436-9
J:174435 Schmutz I, et al., Protein Phosphatase 1 (PP1) Is a Post-Translational Regulator of the Mammalian Circadian Clock. PLoS One. 2011;6(6):e21325
J:176743 Koyanagi S, et al., cAMP-response element (CRE)-mediated transcription by activating transcription factor-4 (ATF4) is essential for circadian expression of the Period2 gene. J Biol Chem. 2011 Sep 16;286(37):32416-23
J:177139 Lee HM, et al., The period of the circadian oscillator is primarily determined by the balance between casein kinase 1 and protein phosphatase 1. Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16451-6
J:177241 Ozber N, et al., Identification of two amino acids in the C-terminal domain of mouse CRY2 essential for PER2 interaction. BMC Mol Biol. 2010;11:69
J:181918 Miki T, et al., PML regulates PER2 nuclear localization and circadian function. EMBO J. 2012;31(6):1427-39
J:183929 Zhao Y, et al., Loss of mPer2 increases plasma insulin levels by enhanced glucose-stimulated insulin secretion and impaired insulin clearance in mice. FEBS Lett. 2012 May 7;586(9):1306-11
J:185950 Padmanabhan K, et al., Feedback regulation of transcriptional termination by the mammalian circadian clock PERIOD complex. Science. 2012 Aug 3;337(6094):599-602
J:189236 Kowalska E, et al., Distinct Roles of DBHS Family Members in the Circadian Transcriptional Feedback Loop. Mol Cell Biol. 2012 Nov;32(22):4585-94
J:198214 Barclay JL, et al., High-fat diet-induced hyperinsulinemia and tissue-specific insulin resistance in Cry-deficient mice. Am J Physiol Endocrinol Metab. 2013 May 15;304(10):E1053-63
J:200473 Schneider K, et al., CAVIN-3 regulates circadian period length and PER:CRY protein abundance and interactions. EMBO Rep. 2012 Dec;13(12):1138-44
J:204645 Zhao WN, et al., CIPC is a mammalian circadian clock protein without invertebrate homologues. Nat Cell Biol. 2007 Mar;9(3):268-75
J:205048 Richards J, et al., A role for the circadian clock protein Per1 in the regulation of aldosterone levels and renal Na+ retention. Am J Physiol Renal Physiol. 2013 Dec 15;305(12):F1697-704
J:205586 Annayev Y, et al., Gene model 129 (gm129) encodes a novel transcriptional repressor that modulates circadian gene expression. J Biol Chem. 2014 Feb 21;289(8):5013-24
J:205840 Bonney S, et al., Cardiac Per2 functions as novel link between fatty acid metabolism and myocardial inflammation during ischemia and reperfusion injury of the heart. PLoS One. 2013;8(8):e71493
J:209477 Ye R, et al., Biochemical analysis of the canonical model for the mammalian circadian clock. J Biol Chem. 2011 Jul 22;286(29):25891-902
J:209490 Brown SA, et al., PERIOD1-associated proteins modulate the negative limb of the mammalian circadian oscillator. Science. 2005 Apr 29;308(5722):693-6
J:210023 Duong HA, et al., Temporal orchestration of repressive chromatin modifiers by circadian clock Period complexes. Nat Struct Mol Biol. 2014 Feb;21(2):126-32
J:210938 Yagita K, et al., Nucleocytoplasmic shuttling and mCRY-dependent inhibition of ubiquitylation of the mPER2 clock protein. EMBO J. 2002 Mar 15;21(6):1301-14
J:212062 Engelen E, et al., Mammalian TIMELESS is involved in period determination and DNA damage-dependent phase advancing of the circadian clock. PLoS One. 2013;8(2):e56623
J:215866 Devos J, et al., Magel2, a Prader-Willi syndrome candidate gene, modulates the activities of circadian rhythm proteins in cultured cells. J Circadian Rhythms. 2011;9(1):12

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