Sequence Detail

ID/Version

O54709 (UniProt | EBI)

Last sequence update: 1999-05-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=NKG2-D type II integral membrane protein;AltName: Full=Killer cell lectin-like receptor subfamily K member 1;AltName: Full=NK cell receptor D;AltName: Full=NKG2-D-activating NK receptor;AltName: CD_antigen=CD314;

Provider

SWISS-PROT

Sequence

Polypeptide 232 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Klrk1	killer cell lectin-like receptor subfamily K, member 1	50	96	3	16

Sequence references in MGI

J:45141 Vance RE, et al., Cloning of a mouse homolog of CD94 extends the family of C-type lectins on murine natural killer cells. Eur J Immunol. 1997 Dec;27(12):3236-41
J:47910 Ho EL, et al., Murine Nkg2d and Cd94 are clustered within the natural killer complex and are expressed independently in natural killer cells. Proc Natl Acad Sci U S A. 1998 May 26;95(11):6320-5
J:63053 Cerwenka A, et al., Retinoic acid early inducible genes define a ligand family for the activating NKG2D receptor in mice. Immunity. 2000 Jun;12(6):721-7
J:78102 Jamieson AM, et al., The role of the NKG2D immunoreceptor in immune cell activation and natural killing. Immunity. 2002 Jul;17(1):19-29
J:80426 Gilfillan S, et al., NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation. Nat Immunol. 2002 Dec;3(12):1150-5
J:88981 Girardi M, et al., Regulation of cutaneous malignancy by gammadelta T cells. Science. 2001 Oct 19;294(5542):605-9
J:92687 Rosen DB, et al., A Structural basis for the association of DAP12 with mouse, but not human, NKG2D. J Immunol. 2004 Aug 15;173(4):2470-8
J:100453 Ogasawara K, et al., Function of NKG2D in natural killer cell-mediated rejection of mouse bone marrow grafts. Nat Immunol. 2005 Sep;6(9):938-45
J:134509 Guerra N, et al., NKG2D-deficient mice are defective in tumor surveillance in models of spontaneous malignancy. Immunity. 2008 Apr;28(4):571-80
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:151878 Zafirova B, et al., Altered NK cell development and enhanced NK cell-mediated resistance to mouse cytomegalovirus in NKG2D-deficient mice. Immunity. 2009 Aug 21;31(2):270-82
J:215590 Zafirova B, et al., Regulation of immune cell function and differentiation by the NKG2D receptor. Cell Mol Life Sci. 2011 Nov;68(21):3519-29
J:219772 Diefenbach A, et al., Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D. Nat Immunol. 2002 Dec;3(12):1142-9