Sequence Detail

ID/Version

O35740 Q6PGA9 O35741 O35742 O35743 O55198 (UniProt | EBI)

Last sequence update: 2012-10-03
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Cbp/p300-interacting transactivator 2;AltName: Full=MSG-related protein 1; Short=MRG-1;AltName: Full=P35srj;

Provider

SWISS-PROT

Sequence

Polypeptide 269 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Cited2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	161	129	3	20

Sequence references in MGI

J:46929 Dunwoodie SL, et al., Msg1 and Mrg1, founding members of a gene family, show distinct patterns of gene expression during mouse embryogenesis. Mech Dev. 1998 Mar;72(1-2):27-40
J:48778 Shioda T, et al., MSG1 and its related protein MRG1 share a transcription activating domain. Gene. 1997 Dec 19;204(1-2):235-41
J:76593 Bamforth SD, et al., Cardiac malformations, adrenal agenesis, neural crest defects and exencephaly in mice lacking Cited2, a new Tfap2 co-activator. Nat Genet. 2001 Dec;29(4):469-74
J:92872 Bamforth SD, et al., Cited2 controls left-right patterning and heart development through a Nodal-Pitx2c pathway. Nat Genet. 2004 Dec;36(11):1189-96
J:97216 Weninger WJ, et al., Cited2 is required both for heart morphogenesis and establishment of the left-right axis in mouse development. Development. 2005 Mar;132(6):1337-48
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:114818 Chou YT, et al., Cited2 modulates TGF-beta-mediated upregulation of MMP9. Oncogene. 2006 Sep 7;25(40):5547-60
J:135126 Val P, et al., Adrenal development is initiated by Cited2 and Wt1 through modulation of Sf-1 dosage. Development. 2007 Jun;134(12):2349-58
J:150743 Buaas FW, et al., The transcription co-factor CITED2 functions during sex determination and early gonad development. Hum Mol Genet. 2009 Aug 15;18(16):2989-3001
J:168841 Lopes Floro K, et al., Loss of Cited2 causes congenital heart disease by perturbing left-right patterning of the body axis. Hum Mol Genet. 2011 Mar 15;20(6):1097-110
J:172915 Glenn DJ, et al., MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression. J Biol Chem. 1999 Dec 17;274(51):36159-67