Sequence Detail

ID/Version

G5E8Q8 (UniProt | EBI)

Last sequence update: 2011-12-14
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Adhesion G protein-coupled receptor F5;AltName: Full=G-protein coupled hepta-helical receptor Ig-hepta; Short=Ig-Hepta {ECO:0000303|PubMed:23922714};AltName: Full=G-protein coupled receptor 116;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 1348 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Adgrf5	adhesion G protein-coupled receptor F5	32	106	4	20

Sequence references in MGI

J:187390 Promel S, et al., Characterization and functional study of a cluster of four highly conserved orphan adhesion-GPCR in mouse. Dev Dyn. 2012 Oct;241(10):1591-602
J:190131 Nie T, et al., Adipose tissue deletion of Gpr116 impairs insulin sensitivity through modulation of adipose function. FEBS Lett. 2012 Oct 19;586(20):3618-25
J:196943 Yang MY, et al., Essential Regulation of Lung Surfactant Homeostasis by the Orphan G Protein-Coupled Receptor GPR116. Cell Rep. 2013 May 30;3(5):1457-64
J:204701 Fukuzawa T, et al., Lung surfactant levels are regulated by Ig-Hepta/GPR116 by monitoring surfactant protein D. PLoS One. 2013;8(7):e69451
J:221769 Bridges JP, et al., Orphan G protein-coupled receptor GPR116 regulates pulmonary surfactant pool size. Am J Respir Cell Mol Biol. 2013 Sep;49(3):348-57
J:243171 Niaudet C, et al., Gpr116 Receptor Regulates Distinctive Functions in Pneumocytes and Vascular Endothelium. PLoS One. 2015;10(9):e0137949
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:298743 Zaidman NA, et al., Adhesion-GPCR Gpr116 (ADGRF5) expression inhibits renal acid secretion. Proc Natl Acad Sci U S A. 2020 Oct 20;117(42):26470-26481
J:340382 Georgiadi A, et al., Orphan GPR116 mediates the insulin sensitizing effects of the hepatokine FNDC4 in adipose tissue. Nat Commun. 2021 May 20;12(1):2999
J:344256 Bridges JP, et al., Regulation of pulmonary surfactant by the adhesion GPCR GPR116/ADGRF5 requires a tethered agonist-mediated activation mechanism. Elife. 2022 Sep 8;11:e69061
J:344464 Rothe J, et al., The adhesion GPCR GPR116/ADGRF5 has a dual function in pancreatic islets regulating somatostatin release and islet development. Commun Biol. 2024 Jan 16;7(1):104