Sequence Detail

ID/Version

G5E845 (UniProt | EBI)

Last sequence update: 2011-12-14
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Potassium channel, subfamily K, member 16;AltName: Full=2P domain potassium channel Talk-1;AltName: Full=Potassium channel subfamily K member 16;AltName: Full=TWIK-related alkaline pH-activated K(+) channel 1; Short=TALK-1 {ECO:00003

Provider

SWISS-PROT

Sequence

Polypeptide 292 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Kcnk16	potassium channel, subfamily K, member 16	6	96	2	8

Sequence references in MGI

J:252881 Vierra NC, et al., Type 2 Diabetes-Associated K+ Channel TALK-1 Modulates beta-Cell Electrical Excitability, Second-Phase Insulin Secretion, and Glucose Homeostasis. Diabetes. 2015 Nov;64(11):3818-28
J:259519 Vierra NC, et al., TALK-1 channels control beta cell endoplasmic reticulum Ca(2+) homeostasis. Sci Signal. 2017 Sep 19;10(497)
J:306486 Vierra NC, et al., TALK-1 reduces delta-cell endoplasmic reticulum and cytoplasmic calcium levels limiting somatostatin secretion. Mol Metab. 2018 Mar;9:84-97
J:344958 Graff SM, et al., TALK-1-mediated alterations of beta-cell mitochondrial function and insulin secretion impair glucose homeostasis on a diabetogenic diet. Cell Rep. 2024 Jan 23;43(1):113673