Sequence Detail

ID/Version

B2RXV4 (UniProt | EBI)

Last sequence update: 2008-07-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Choline/ethanolamine transporter FLVCR1;AltName: Full=Feline leukemia virus subgroup C receptor-related protein 1; Short=Feline leukemia virus subgroup C receptor {ECO:0000250|UniProtKB:Q9Y5Y0};AltName: Full=Heme transporter FLVCR1 {

Provider

SWISS-PROT

Sequence

Polypeptide 560 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Flvcr1	feline leukemia virus subgroup C cellular receptor 1	48	107	3	12

Sequence references in MGI

J:132057 Keel SB, et al., A heme export protein is required for red blood cell differentiation and iron homeostasis. Science. 2008 Feb 8;319(5864):825-8
J:194202 Chiabrando D, et al., The mitochondrial heme exporter FLVCR1b mediates erythroid differentiation. J Clin Invest. 2012 Dec 3;122(12):4569-79
J:204083 Byon JC, et al., FLVCR is necessary for erythroid maturation, may contribute to platelet maturation, but is dispensable for normal hematopoietic stem cell function. Blood. 2013 Oct 17;122(16):2903-10
J:337002 Kenny TC, et al., Integrative genetic analysis identifies FLVCR1 as a plasma-membrane choline transporter in mammals. Cell Metab. 2023 Jun 6;35(6):1057-1071.e12