Sequence Detail

ID/Version

A2ARP9 Q91ZP5 A2RSK0 (UniProt | EBI)

Last sequence update: 2007-07-24
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Cation channel sperm-associated protein 2; Short=CatSper2;

Provider

SWISS-PROT

Sequence

Polypeptide 588 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Catsper2	cation channel, sperm associated 2	33	96	2	26

Sequence references in MGI

J:78669 Quill TA, et al., A voltage-gated ion channel expressed specifically in spermatozoa. Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12527-31
J:86972 Quill TA, et al., Hyperactivated sperm motility driven by CatSper2 is required for fertilization. Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):14869-74
J:118812 Marquez B, et al., Contributions of extracellular and intracellular Ca2+ to regulation of sperm motility: Release of intracellular stores can hyperactivate CatSper1 and CatSper2 null sperm. Dev Biol. 2007 Mar 1;303(1):214-21
J:128548 Carlson AE, et al., Identical phenotypes of CatSper1 and CatSper2 null sperm. J Biol Chem. 2005 Sep 16;280(37):32238-44
J:182472 Chung JJ, et al., A novel gene required for male fertility and functional CATSPER channel formation in spermatozoa. Nat Commun. 2011 Jan 11;2:153
J:314092 Lin S, et al., Structure of a mammalian sperm cation channel complex. Nature. 2021 Jul;595(7869):746-750
J:321418 Hwang JY, et al., C2cd6-encoded CatSpertau targets sperm calcium channel to Ca(2+) signaling domains in the flagellar membrane. Cell Rep. 2022 Jan 18;38(3):110226
J:354398 Lishko PV, et al., Progesterone activates the principal Ca2+ channel of human sperm. Nature. 2011 Mar 17;471(7338):387-91