Sequence Detail

ID/Version

A2ARA8 O70304 Q8C0H7 Q8BRG3 Q3UXV8 (UniProt | EBI)

Last sequence update: 2007-02-20
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=Integrin alpha-8;Contains: RecName: Full=Integrin alpha-8 heavy chain;Contains: RecName: Full=Integrin alpha-8 light chain;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 1062 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Itga8	integrin alpha 8	38	110	3	9

Sequence references in MGI

J:38838 Muller U, et al., Integrin alpha8beta1 is critically important for epithelial-mesenchymal interactions during kidney morphogenesis. Cell. 1997 Mar 7;88(5):603-13
J:61486 Littlewood Evans A, et al., Stereocilia defects in the sensory hair cells of the inner ear in mice deficient in integrin alpha8beta1. Nat Genet. 2000 Apr;24(4):424-8
J:70545 Brandenberger R, et al., Identification and characterization of a novel extracellular matrix protein nephronectin that is associated with integrin alpha8beta1 in the embryonic kidney. J Cell Biol. 2001 Jul 23;154(2):447-58
J:85775 Wagner TE, et al., Expression of the integrin subunit alpha8 in murine lung development. J Histochem Cytochem. 2003 Oct;51(10):1307-15
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:122519 Linton JM, et al., The ECM protein nephronectin promotes kidney development via integrin {alpha}8{beta}1-mediated stimulation of Gdnf expression. Development. 2007 Jul;134(13):2501-9
J:286199 Hartner A, et al., The alpha8 integrin chain affords mechanical stability to the glomerular capillary tuft in hypertensive glomerular disease. Am J Pathol. 2002 Mar;160(3):861-7
J:286571 Denda S, et al., Identification of osteopontin as a novel ligand for the integrin alpha8 beta1 and potential roles for this integrin-ligand interaction in kidney morphogenesis. Mol Biol Cell. 1998 Jun;9(6):1425-35
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89