Sequence Detail

ID/Version

A1Z198 F6R9S5 Q2LKV8 Q2LK61 (UniProt | EBI)

Last sequence update: 2007-02-06
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=NACHT, LRR and PYD domains-containing protein 1b allele 2 {ECO:0000303|PubMed:16429160}; EC=3.4.-.- {ECO:0000250|UniProtKB:Q2LKW6};Contains: RecName: Full=NACHT, LRR and PYD domains-containing protein 1b, C-terminus {ECO:0000305};

Provider

SWISS-PROT

Sequence

Polypeptide 1177 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Nlrp1b	NLR family, pyrin domain containing 1B	40	96	3	7

Sequence references in MGI

J:99748 Boyden ED, et al., Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin. Nat Genet. 2006;38(2):240-244
J:168096 Moayeri M, et al., Inflammasome sensor Nlrp1b-dependent resistance to anthrax is mediated by caspase-1, IL-1 signaling and neutrophil recruitment. PLoS Pathog. 2010;6(12):e1001222
J:169881 Hsu LC, et al., A NOD2-NALP1 complex mediates caspase-1-dependent IL-1beta secretion in response to Bacillus anthracis infection and muramyl dipeptide. Proc Natl Acad Sci U S A. 2008 Jun 3;105(22):7803-8
J:194517 Sastalla I, et al., Transcriptional analysis of the three Nlrp1 paralogs in mice. BMC Genomics. 2013 Mar 18;14(1):188
J:206165 Ewald SE, et al., NLRP1 is an inflammasome sensor for Toxoplasma gondii. Infect Immun. 2014 Jan;82(1):460-8
J:242786 Ydens E, et al., Nlrp6 promotes recovery after peripheral nerve injury independently of inflammasomes. J Neuroinflammation. 2015 Aug 08;12:143
J:244194 Van Opdenbosch N, et al., Activation of the NLRP1b inflammasome independently of ASC-mediated caspase-1 autoproteolysis and speck formation. Nat Commun. 2014;5:3209