Cdkn1c<em2(cre/ERT2)Kei> - Alimentary System Recombinase Activity Detail MGI Mouse

Cdkn1c^{em2(cre/ERT2)Kei} - Alimentary System
Recombinase Activity Detail

Allele Information | Tissue Information | Images | Recombinase Activity | References

Allele Information

Allele:

Cdkn1c^{em2(cre/ERT2)Kei}
cyclin dependent kinase inhibitor 1C; endonuclease-mediated mutation 2, Keiichi I Nakayama

Driver: Cdkn1c
Type: Endonuclease-mediated (Inducible, Recombinase)

Inducer:

tamoxifen

Synonym:

p57-CreER^T2

Molecular description:

Using CRISPR/Cas9 system, the T2A-cre/ERT2 cassette was inserted in-frame into the endogenous Cdkn1c (p57) coding sequence immediately 5 to the only TGA codon at this locus in ES cells. Single colony ES cell clones that had undergone homologous recombination were then expanded and injected into C57BL/6 mouse blastocysts to generate chimeric mice.

Find mice (IMSR):

Mouse Strains: 0 strains available Cell Lines: 0 lines available

Tissue Information

Alimentary System

Other recombinase alleles with activity in Alimentary System tissues:

7630403G23Rik^{Tg(Th-cre)1Tmd}, A4gnt^{tm1.1(cre/ERT2)Niba}, Abcg2^{tm1.1(cre/Esr1*)Jvbe}, Agrp^tm1(cre)Lowl ...(more)

Images

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J:323000 Fig. 4

Recombinase Activity

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Assays Genotypic Background Result Notes

References

All for this allele:

2 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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