Fgf8<tm3.1(cre/Esr1*)Moon> - Limbs Recombinase Activity Detail MGI Mouse

Fgf8^{tm3.1(cre/Esr1*)Moon} - Limbs
Recombinase Activity Detail

Allele Information | Tissue Information | Recombinase Activity | References

Allele Information

Allele:

Fgf8^{tm3.1(cre/Esr1*)Moon}
fibroblast growth factor 8; targeted mutation 3.1, Anne M Moon

Driver: Fgf8
Type: Targeted (Inducible, Recombinase)

Inducer:

tamoxifen

Synonym:

Fgf8^mcm

Molecular description:

The targeting construct inserted an IRES sequence followed by the mER:Cre:mER cDNA encoding a fusion protein with two copies of the mouse estrogen receptor (mER) flanking Cre recombinase, and a Neomycin resistance (NeoR) selection cassette flanked by Frt recombination sites into an Eag1 site in the Fgf8 gene located 36 bp 3 of the Fgf8 stop codon and 5 to the endogenous polyadenylation sequence. The linearized targeting vector was electroporated into mouse embryonic stem cells and subjected to selection. Flp-recombinase excised the NeoR.

Find mice (IMSR):

Mouse Strains: 0 strains available Cell Lines: 0 lines available

Additional Tissues:

Fgf8^{tm3.1(cre/Esr1*)Moon} activity also observed in:
head, sensory organs

Tissue Information

Limbs

Other recombinase alleles with activity in Limbs tissues:

Acan^em2(dre)Smoc, Acan^{tm1(cre/ERT2)Crm}, Alpl^tm1(cre)Nagy, Cacna1h^{tm2.1(cre)Glwn} ...(more)

Recombinase Activity

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Assays Genotypic Background Result Notes

References

All for this allele:

3 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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