Nkx2-5<tm1.1(cre/ERT2)Rard> - Renal & Urinary System Recombinase Activity Detail MGI Mouse

Nkx2-5^{tm1.1(cre/ERT2)Rard} - Renal & Urinary System
Recombinase Activity Detail

Allele Information | Images | Recombinase Activity | References

Allele Information

Allele:

Nkx2-5^{tm1.1(cre/ERT2)Rard}
NK2 homeobox 5; targeted mutation 1.1, Reza Ardehali

Driver: Nkx2-5
Type: Targeted (Inducible, Recombinase)

Inducer:

tamoxifen

Synonym:

Nkx2-5/CreER

Molecular description:

Using homologous recombination in ES cells an internal ribosome entry site (IRES) linked to the gene encoding a nuclear-localizing recombinase cre fused to ERT2 and a hygromycin resistance gene cassette (pgk-HYGROpA) flanked by yeast flp recombinase target (frt) sites was inserted into the 3' UTR of the endogenous locus. pgk-HYGRO-pA cassette was removed by crossing to Flp recombinase gene expressing mice.

Find mice (IMSR):

Mouse Strains: 0 strains available Cell Lines: 0 lines available

Additional Tissues:

Nkx2-5^{tm1.1(cre/ERT2)Rard} activity also observed in:
cardiovascular system

Images

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J:243421 Fig. 3

Recombinase Activity

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Assays Genotypic Background Result Notes

References

All for this allele:

2 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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