Nkx2-5tm1.1(cre/ERT2)Rard
Targeted Allele Detail
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Symbol: |
Nkx2-5tm1.1(cre/ERT2)Rard |
Name: |
NK2 homeobox 5; targeted mutation 1.1, Reza Ardehali |
MGI ID: |
MGI:6791388 |
Synonyms: |
Nkx2-5/CreER |
Gene: |
Nkx2-5 Location: Chr17:27057638-27063962 bp, - strand Genetic Position: Chr17, 13.6 cM
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Alliance: |
Nkx2-5tm1.1(cre/ERT2)Rard page
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Germline Transmission: |
Earliest citation of germline transmission:
J:243421
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Inducible, Recombinase) |
Inducer: |
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tamoxifen |
Mutation: |
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Insertion
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Nkx2-5tm1.1(cre/ERT2)Rard expression driven by
1 gene
Knock-in expression driven by:
Organism |
Driver Gene |
Note |
mouse |
Nkx2-5 (MGI:97350) |
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Mutation details: Using homologous recombination in ES cells an internal ribosome entry site (IRES) linked to the gene encoding a nuclear-localizing recombinase cre fused to ERT2 and a hygromycin resistance gene cassette (pgk-HYGROpA) flanked by yeast flp recombinase target (frt) sites was inserted into the 3' UTR of the endogenous locus. pgk-HYGRO-pA cassette was removed by crossing to Flp recombinase gene expressing mice.
(J:243421)
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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Nkx2-5
(mouse)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Nkx2-5 Mutation: |
21 strains or lines available
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Original: |
J:243421 Ranjbarvaziri S, et al., Generation of Nkx2-5/CreER transgenic mice for inducible Cre expression in developing hearts. Genesis. 2017 Aug;55(8) |
All: |
2 reference(s) |
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