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Pdgfratm1.1(flpo)Leol - Embryo-other
Recombinase Activity Detail
Allele Information
Allele:
Pdgfratm1.1(flpo)Leol
platelet derived growth factor receptor, alpha polypeptide; targeted mutation 1.1, Lorin E Olson 		Driver: Pdgfra
Type: Targeted (Constitutively active, Recombinase)
Synonym: aRdeltaK.Flp, PdgfradeltaK.Flp
Molecular description: The targeting cassette consisting of a SA.lox.Neo/Stop.lox-PDGFRaK.T2A.Flp cassette replaced the exons 2-4 of the endogenous Pdgfra gene. The PDGFRaK is a mouse Pdgfra gene cDNA with a point mutation (D842V) renders it constitutively active. Cre-mediated recombination removed lox.Neo/Stop.lox cassette from Pdgfratm1(flpo)Leol enabling the expression of the constitutively active Pdgfra gene with a point mutation (D842V) and the flpo recombinase.
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Additional Tissues: Pdgfratm1.1(flpo)Leol activity also observed in:
head, mesenchyme
Tissue Information
Embryo-other Other recombinase alleles with activity in Embryo-other tissues:
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory