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The Mouse Gene Expression Information Resource Project

The Mouse Gene Expression Information Resource (MGEIR) is being developed collaboratively by the Gene Expression Database (GXD) project and the Edinburgh Mouse Atlas project. Ultimately, the MGEIR will provide the scientific community with a unified resource that combines text-based and 3D graphical methods to store, display, and analyze mouse developmental gene expression information.

The Mouse Gene Expression Information Resource resource will integrate the following components:

Current Status and Acknowledgements

GXD has been developed and continues to be maintained and enhanced by the GXD team at the Jackson Laboratory.

The Dictionary of Anatomical Terms for structures present during embryonic development (Theiler Stages 1 - 26) has been developed and continues to be refined at the Department of Biomedical Sciences, University of Edinburgh, Scotland and the MRC Human Genetics Unit, Edinburgh. A dictionary of anatomical terms for the postnatal mouse (Theiler Stage 28) has been developed and is currently being refined by the GXD project. It is available for viewing here.

The 3D Atlas / Graphical Gene Expression Database is being developed at the MRC Human Genetics Unit, Edinburgh and at the Department of Biomedical Sciences, University of Edinburgh, Scotland.

The GXD Project is supported by NIH grant HD062499. Work at Edinburgh is supported by the MRC, the BBSRC, and by the European Science Foundation.

Selected References


Smith CM, Finger JH, Hayamizu TF, McCright IJ, Xu J, Berghout J, Campbell J, Corbani LE, Forthofer KL, Frost PJ, Miers D, Shaw DR, Stone KR, Eppig JT, Kadin JA, Richardson JE, Ringwald M. The mouse Gene Expression Database (GXD): 2014 update. Nucleic Acids Res. 2014 Jan 1;42(D1):D818-D824. NAR. PubMed

Hayamizu TF, Wicks MN, Davidson DR, Burger A, Ringwald M, Baldock RA. 2013. EMAP/EMAPA ontology of mouse developmental anatomy: 2013 update. J Biomed Semantics. 2013 Aug 26;4(1):15. PubMed

Ringwald M, Wu C, Su AI. 2012. BioGPS and GXD: mouse gene expression data-the benefits and challenges of data integration. Mamm Genome. 2012 Oct;23(9-10):550-8. PubMed

Finger JH, Smith CM, Hayamizu TF, McCright IJ, Eppig JT, Kadin JA, Richardson JE, Ringwald M. 2011. The mouse Gene Expression Database (GXD): 2011 update. Nucleic Acids Res 39(suppl 1): D835-D841. NAR PubMed

Smith CM, Finger JH, Hayamizu TF, McCright IJ, Eppig JT, Kadin JA, Richardson JE, Ringwald, M. The mouse Gene Expression Database (GXD): 2007 update. Nucleic Acids Res 2007 35(Database issue):D618-D623. NAR   PubMed.

Hayamizu TF, Mangan M, Corradi JP, Kadin JA, Ringwald M. The Adult Mouse Anatomical Dictionary: a tool for annotating and integrating data. Genome Biol, 2005;6:R29   PubMed.

Hill DP, Begley DA, Finger JH, Hayamizu TF, McCright IJ, Smith CM, Beal JS, Corbani LE, Blake JA, Eppig JT, Kadin JA, Richardson JE, Ringwald M. The Mouse Gene Expression Database (GXD): updates and enhancements. Nucleic Acids Res 2004; 32:D568-D571. NAR   PubMed

Begley DA, Ringwald M. 2002. Electronic tools to manage gene expression data. Trends Genet 18:108-110.

Ringwald M, Eppig JT, Begley DA, Corradi JP, McCright IJ, Hayamizu TF, Hill DP, Kadin JA, Richardson JE. 2001. The Mouse Gene Expression Database (GXD). Nucleic Acids Res 29:98-101.  PubMed

Ringwald M, Eppig JT, Richardson JE. 2000. GXD: integrated access to gene expression data for the laboratory mouse. Trends Genet 16:188-190. PubMed

Bard JBL, Kaufman MH, Dubreuil C, Brune RM, Burger A, Baldock RA and Davidson DR. 1998. An internet-accessible database of mouse developmental anatomy based on a systematic nomenclature. Mech Dev 74:111-120.

Ringwald M, Baldock R, Bard J, Kaufmann M, Eppig JT, Richardson JE, Nadeau JH, Davidson D. 1994. A database for mouse development. Science 265: 2033-2034. PubMed

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory