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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Mark2
MAP/microtubule affinity regulating kinase 2
MGI:99638
67 phenotypes from 2 alleles in 2 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background
Annotated Term Reference
Mark2Gt(pSABetageo)38Bss/Mark2+
involves: 129S2/SvPas * MF1
decreased body weight J:57958
postnatal growth retardation J:57958
Mark2Gt(pSABetageo)38Bss/Mark2Gt(pSABetageo)38Bss
involves: 129S2/SvPas * MF1
decreased body weight J:57958
decreased circulating progesterone level J:57958
decreased circulating prolactin level J:57958
decreased corpora lutea number J:57958
decreased epididymis weight J:57958
decreased ovary weight J:57958
decreased seminal vesicle weight J:57958
decreased testis weight J:57958
decreased uterus weight J:57958
enlarged heart J:57958
enlarged lung J:57958
increased brain size J:57958
increased prolactin level J:57958
infertility J:57958
postnatal growth retardation J:57958
reduced female fertility J:57958
small pituitary gland J:57958
Mark2tm1Hpw/Mark2+
involves: 129X1/SvJ * C57BL/6
decreased body weight J:120128
hemoglobinuria J:68830
increased urine protein level J:68830
rectal prolapse J:68830
Mark2tm1Hpw/Mark2tm1Hpw
involves: 129X1/SvJ * C57BL/6
abnormal CD4-positive, alpha beta T cell morphology J:68830
abnormal eating behavior J:120128
abnormal glomerular capillary morphology J:68830
abnormal glucose homeostasis J:120128
abnormal humoral immune response J:68830
abnormal immune system physiology J:68830
abnormal spleen B cell follicle morphology J:68830
decreased B cell proliferation J:68830
decreased body length J:120128
decreased body weight J:68830, J:120128
decreased brown adipose tissue amount J:120128, J:163905
decreased circulating adiponectin level J:163905
decreased circulating cholesterol level J:120128
decreased circulating insulin level J:120128
decreased circulating insulin-like growth factor I level J:120128
decreased circulating leptin level J:120128
decreased circulating triglyceride level J:120128
decreased embryo weight J:120128
decreased IgG3 level J:68830
decreased IgM level J:68830
decreased litter size J:68830
decreased percent body fat/body weight J:120128
decreased susceptibility to diet-induced obesity J:120128
decreased susceptibility to hepatic steatosis J:120128
decreased susceptibility to weight gain J:163905
decreased white adipose tissue amount J:120128, J:163905
enlarged lymph nodes J:68830
enlarged spleen J:68830
glomerulonephritis J:68830
hemoglobinuria J:68830
hypoglycemia J:120128
improved glucose tolerance J:120128
increased adipocyte glucose uptake J:120128
increased B cell number J:68830
increased B cell proliferation J:68830
increased basal metabolism J:120128
increased energy expenditure J:120128
increased insulin sensitivity J:120128
increased interferon-gamma secretion J:68830
increased interleukin-4 secretion J:68830
increased renal glomerulus lobularity J:68830
increased spleen weight J:68830
increased urine protein level J:68830
kidney inflammation J:68830
lung inflammation J:68830
lymph node hyperplasia J:68830
mesangial cell hyperplasia J:68830
postnatal growth retardation J:68830
postnatal lethality, incomplete penetrance J:68830
rectal prolapse J:68830
salivary gland inflammation J:68830
spleen hyperplasia J:68830

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/26/2020
MGI 6.15
The Jackson Laboratory