Nr3c2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Nr3c2
nuclear receptor subfamily 3, group C, member 2
MGI:99459

41 phenotypes from 6 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Nr3c2^m1Btlr/Nr3c2^m1Btlr C57BL/6J-Nr3c2^m1Btlr	decreased body weight	J:225269
Nr3c2^tm1.1Ics/Nr3c2^tm1.1Ics Tg(Acta2-cre/ERT2)#Pcn/0 involves: 129S2/SvPas * FVB/N	abnormal muscle tone	J:193438
	abnormal redox activity	J:193438
	abnormal vasoconstriction	J:193438
	abnormal vasodilation	J:193438
	normal cardiovascular system phenotype	J:193438
	decreased heart weight	J:193438
	decreased systemic arterial systolic blood pressure	J:193438
	decreased vasoconstriction	J:193438
	increased vasoconstriction	J:193438
	increased vasodilation	J:193438
	normal renal/urinary system phenotype	J:193438
Nr3c2^tm1Gsc/Nr3c2⁺ involves: 129P2/OlaHsd * C57BL/6	abnormal renal sodium ion transport	J:77285
	increased circulating aldosterone level	J:77285
	increased circulating angiotensin II level	J:77285
	increased circulating renin level	J:77285
	increased renin activity	J:77285
	increased urine sodium level	J:77285
Nr3c2^tm1Gsc/Nr3c2^tm1Gsc involves: 129P2/OlaHsd * C57BL/6	abnormal extraglomerular mesangial cell morphology	J:77285
	abnormal ion homeostasis	J:77285
	abnormal juxtaglomerular apparatus morphology	J:77285
	abnormal juxtaglomerular cell morphology	J:77285
	abnormal macula densa morphology	J:77285
	abnormal renal glomerulus morphology	J:77285
	abnormal renal sodium ion transport	J:77285
	abnormal renal sodium reabsorption	J:77285
	decreased circulating sodium level	J:77285
	dehydration	J:77285
	hypovolemia	J:77285
	increased circulating aldosterone level	J:77285
	increased circulating angiotensin II level	J:77285
	increased circulating potassium level	J:77285
	increased circulating renin level	J:77285
	increased hematocrit	J:77285
	increased renin activity	J:77285
	increased urine sodium level	J:77285
	postnatal lethality, complete penetrance	J:77285
	normal renal/urinary system phenotype	J:77285
	weight loss	J:77285
Nr3c2^tm1Krst/Nr3c2^tm1Krst Tg(Camk2a-cre)2Gsc/? involves: FVB/N	abnormal miniature excitatory postsynaptic currents	J:104691
Nr3c2^tm2.1Gsc/Nr3c2^tm2.1Gsc involves: C57BL/6	postnatal lethality	J:104549
Nr3c2^tm2Gsc/Nr3c2^tm2Gsc Tg(Aqp2-cre/ERT2)4Gsc/0 involves: C57BL/6 * FVB/N	normal homeostasis/metabolism phenotype	J:169670
	increased circulating aldosterone level	J:169670
	increased urine sodium level	J:169670
	polyuria	J:169670
Nr3c2^tm2Gsc/Nr3c2^tm2Gsc Tg(Camk2a-cre)2Gsc/0 involves: 129P2/OlaHsd * C57BL/6 * FVB/N	abnormal hippocampal mossy fiber morphology	J:104549
	abnormal response to novel object	J:104549
	abnormal spatial learning	J:104549
	abnormal spatial working memory	J:104549
	normal behavior/neurological phenotype	J:104549

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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