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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Hsp90b1
heat shock protein 90, beta (Grp94), member 1
MGI:98817
34 phenotypes from 4 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Hsp90b1tm1.2Alee/Hsp90b1tm1.2Alee
involves: 129/Sv * C57BL/6J * FVB/N
abnormal fetal cardiomyocyte morphology J:160900
decreased embryo size J:160900
disorganized embryonic tissue J:160900
embryonic lethality between implantation and placentation, complete penetrance J:160900
Hsp90b1tm1Yarg/Hsp90b1tm1Yarg
B6.129X1-Hsp90b1tm1Yarg
abnormal cell differentiation J:146397
abnormal developmental patterning J:146397
abnormal embryonic-extraembryonic boundary morphology J:146397
abnormal endoderm development J:146397
abnormal extraembryonic endoderm formation J:146397
abnormal extraembryonic tissue morphology J:146397
abnormal germ layer development J:146397
abnormal left-right axis patterning J:146397
absent amnion J:146397
absent chorion J:146397
absent proamniotic cavity J:146397
decreased embryo size J:146397
embryonic growth arrest J:146397
embryonic lethality between implantation and somite formation, complete penetrance J:146397
failure of primitive streak formation J:146397
Hsp90b1tm1Zhli/Hsp90b1tm1.1Zhli
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd * 129S/SvEv
abnormal cytokine secretion J:118427
abnormal inflammatory response J:118427
abnormal macrophage physiology J:118427
increased susceptibility to bacterial infection J:118427
premature death J:118427
Hsp90b1tm1Zhli/Hsp90b1tm1.1Zhli
Tg(Ddx4-cre)1Dcas/0
involves: 129S/SvEv * FVB
abnormal acrosome morphology J:168319
abnormal sperm head morphology J:168319
abnormal sperm midpiece morphology J:168319
asthenozoospermia J:168319
enlarged sperm head J:168319
globozoospermia J:168319
male infertility J:168319
normal reproductive system phenotype J:168319
Hsp90b1tm1Zhli/Hsp90b1tm1Zhli
Tg(Tyr-cre/ERT2)13Bos/0
B6.Cg-Tg(Tyr-cre/ERT2)13Bos Hsp90b1tm1Zhli
abnormal hair follicle melanogenesis J:265851
diluted coat color J:265851
reduced hair shaft melanin granule number J:265851

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory