90 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Ncoa1tm1Bwo/Ncoa1tm1Bwo Thratm2Jas/Thratm2Jas B6.129-Thratm2Jas Ncoa1tm1Bwo	abnormal response/metabolism to endogenous compounds	J:126521
	decreased circulating thyroid-stimulating hormone level	J:126521
	increased circulating thyroid-stimulating hormone level	J:126521
	increased circulating thyroxine level	J:126521
	increased circulating triiodothyronine level	J:126521
Thratm1Jas/Thra+ Thrbtm1Olc/Thrbtm1Olc involves: 129/Sv * 129S1/Sv * 129X1/SvJ	postnatal growth retardation	J:52829
Thratm1Jas/Thratm1Jas Thrbtm1Olc/Thrbtm1Olc involves: 129/Sv * 129S1/Sv * 129X1/SvJ	abnormal long bone epiphyseal plate morphology	J:52829
	abnormal small intestine morphology	J:52829
	abnormal thyroid follicle morphology	J:52829
	decreased body weight	J:52829
	decreased small intestinal villus size	J:52829
	delayed intestine development	J:52829
	delayed skeletal maturation	J:52829
	increased circulating thyroid-stimulating hormone level	J:52829
	increased circulating thyroxine level	J:52829
	increased triiodothyronine level	J:52829
	postnatal growth retardation	J:52829
	premature death	J:52829
	thyroid gland hyperplasia	J:52829
Thratm1Syc/Thra+ involves: 129S6/SvEvTac	decreased body weight	J:95397
	decreased cardiac muscle cell glucose uptake	J:95397
	decreased mean systemic arterial blood pressure	J:95397
	small heart	J:95397
Thratm1Syc/Thra+ involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss	abnormal bone mineral content	J:217018
	abnormal bone mineralization	J:103351, J:217018
	abnormal bone remodeling	J:217018
	abnormal bone strength	J:217018
	abnormal bone structure	J:103351
	abnormal compact bone morphology	J:103351
	abnormal hormone level	J:217018
	abnormal joint morphology	J:217018
	abnormal long bone diaphysis morphology	J:217018
	abnormal long bone epiphyseal ossification zone morphology	J:103351
	abnormal long bone epiphyseal plate morphology	J:103351
	abnormal long bone epiphyseal plate proliferative zone	J:103351
	abnormal long bone metaphysis morphology	J:217018
	abnormal osteoclast physiology	J:217018
	abnormal trabecular bone morphology	J:103351
	decreased bone mineral content	J:217018
	decreased bone resorption	J:217018
	decreased length of long bones	J:217018
	decreased osteoclast cell number	J:217018
	decreased width of hypertrophic chondrocyte zone	J:103351
	delayed cranial suture closure	J:103351
	delayed endochondral bone ossification	J:103351, J:217018
	delayed intramembranous bone ossification	J:103351
	increased bone mineral content	J:217018
	increased bone trabecula number	J:217018
	increased compact bone thickness	J:217018
	increased compact bone volume	J:217018
	increased diameter of long bones	J:217018
	increased long bone epiphyseal plate size	J:217018
	increased thyroid-stimulating hormone level	J:217018
	increased trabecular bone thickness	J:217018
	increased trabecular bone volume	J:217018
	increased triiodothyronine level	J:217018
	large fontanelles	J:103351
	postnatal growth retardation	J:103351
	short tibia	J:103351
	short ulna	J:103351
	wide cranial sutures	J:103351
Thratm1Syc/Thra+ involves: 129S6/SvEvTac * NIH Black Swiss	decreased activity of thyroid gland	J:73446
	decreased body length	J:73446
	decreased body weight	J:73446
	decreased litter size	J:73446
	increased circulating thyroid-stimulating hormone level	J:73446
	increased circulating triiodothyronine level	J:73446
	premature death	J:73446
	reduced female fertility	J:73446
	reduced fertility	J:73446
	reduced male fertility	J:73446
Thratm1Ven/Thra+ Thrbtm1Df/Thrbtm1Df B6.129-Thratm1Ven Thrbtm1Df	increased or absent threshold for auditory brainstem response	J:73382
Thratm1Ven/Thratm1Ven Thrbtm1Df/Thrb+ B6.129-Thratm1Ven Thrbtm1Df	normal hearing/vestibular/ear phenotype	J:73382
Thratm1Ven/Thratm1Ven Thrbtm1Df/Thrbtm1Df B6.129-Thratm1Ven Thrbtm1Df	abnormal auditory brainstem response	J:73382
	abnormal pituitary hormone level	J:117324
	abnormal sperm motility	J:117324
	decreased body weight	J:117324
	decreased follicle stimulating hormone level	J:117324
	decreased growth hormone level	J:117324
	decreased luteinizing hormone level	J:117324
	decreased prolactin level	J:117324
	decreased testis weight	J:117324
	female infertility	J:73382
	increased thyroid-stimulating hormone level	J:117324
Thratm1Ven/Thratm1Ven Thrbtm1Df/Thrbtm1Df involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6	increased circulating thyroid-stimulating hormone level	J:95391
	increased circulating thyroxine level	J:95391
	increased circulating triiodothyronine level	J:95391
	normal neoplasm	J:95391
	small pituitary gland	J:95391
Thratm1Ven/Thratm1Ven Thrbtm1Df/Thrbtm1Df involves: 129P2/OlaHsd * 129S1/Sv * BALB/c * C57BL/6J	abnormal cochlear inner hair cell physiology	J:73382
	abnormal cochlear outer hair cell physiology	J:73382
	abnormal organ of Corti morphology	J:73382
	abnormal pillar cell morphology	J:73382
	abnormal tectorial membrane morphology	J:73382
	abnormal tectorial membrane striated-sheet matrix morphology	J:73382
	decreased body size	J:73382
	decreased cochlear outer hair cell electromotility	J:73382
	decreased endocochlear potential	J:73382
	delayed inner ear development	J:73382
	enlarged tectorial membrane	J:73382
	female infertility	J:73382
	increased susceptibility to xenobiotic induced morbidity/mortality	J:73382
Thratm2Ven/Thra+ Thrbtm1Df/Thrbtm1Df involves: 129P2/OlaHsd * BALB/c * C57BL/6J	normal hearing/vestibular/ear phenotype	J:118402
	postnatal growth retardation	J:118402
Thratm2Ven/Thratm2Ven Thrbtm1Df/Thrbtm1Df involves: 129P2/OlaHsd * BALB/c * C57BL/6J	abnormal thyroid follicle morphology	J:118402
	abnormal thyroid hormone level	J:118402
	decreased circulating thyroxine level	J:118402
	decreased circulating triiodothyronine level	J:118402
	normal hearing/vestibular/ear phenotype	J:118402
	postnatal growth retardation	J:118402
Thratm3Ven/Thra+ Thrbtm1Df/Thrb+ involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6NCrl	abnormal postnatal growth	J:100290
	decreased body weight	J:100290
Thratm3Ven/Thra+ Thrbtm1Df/Thrbtm1Df involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6NCrl	decreased body weight	J:100290
Thratm3Ven/Thratm3Ven Thrbtm1Df/Thrbtm1Df involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6NCrl	preweaning lethality, complete penetrance	J:100290