36 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Hprt1tm1.1(CAG-Smpd1)Jhkh/Hprt1+ involves: 129P2/OlaHsd * C57BL/6	abnormal ceramide level	J:199833
	abnormal depression-related behavior	J:199833
	abnormal neuron differentiation	J:199833
	abnormal physiological response to xenobiotic	J:199833
Smpd1tm1Esc/Smpd1+ involves: 129S1/Sv * C57BL/6J	abnormal immune system cell morphology	J:70489
Smpd1tm1Esc/Smpd1tm1Esc involves: 129S1/Sv	abnormal ceramide level	J:199833
	abnormal depression-related behavior	J:199833
	abnormal neuron differentiation	J:199833
	abnormal physiological response to xenobiotic	J:199833
Smpd1tm1Esc/Smpd1tm1Esc involves: 129S1/Sv * C57BL/6J	abnormal apoptosis	J:35076
	abnormal granulocyte physiology	J:81982
	abnormal lipid homeostasis	J:26732
	abnormal male germ cell morphology	J:78875
	asthenozoospermia	J:78875
	ataxia	J:26732
	cerebellum atrophy	J:26732
	decreased body weight	J:26732
	decreased brain size	J:26732
	hunched posture	J:26732
	normal immune system phenotype	J:44401
	impaired sperm capacitation	J:78875
	increased circulating HDL cholesterol level	J:26732
	increased macrophage derived foam cell number	J:81982
	increased susceptibility to bacterial infection	J:81982
	lethargy	J:26732
	midbrain atrophy	J:26732
	premature death	J:26732
	Purkinje cell degeneration	J:26732
	normal reproductive system phenotype	J:78875
	teratozoospermia	J:78875
	tremors	J:26732
Smpd1tm1Wst/Smpd1tm1Wst involves: 129P2/OlaHsd * C57BL/6	abnormal cerebral cortex morphology	J:26748
	abnormal choroid plexus morphology	J:26748
	abnormal lipid homeostasis	J:26748
	abnormal pulmonary alveolus morphology	J:26748
	ataxia	J:26748
	enlarged liver	J:26748
	enlarged spleen	J:26748
	gliosis	J:26748
	hepatosplenomegaly	J:26748
	impaired coordination	J:26748
	increased macrophage derived foam cell number	J:26748
	premature death	J:26748
	Purkinje cell degeneration	J:26748
	respiratory distress	J:26748
	tremors	J:26748