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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Prf1
perforin 1 (pore forming protein)
MGI:97551
38 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Bmgr2C57BL/6J/?
Prf1tm1Sdz/Prf1tm1Sdz
involves: 129S6/SvEvTac * C57BL/6J 		abnormal response to transplant J:116666
Bmgr3129S6/SvEvTac/Bmgr3129S6/SvEvTac
Prf1tm1Sdz/Prf1tm1Sdz
involves: 129S6/SvEvTac * C57BL/6J 		abnormal response to transplant J:116666
Bmgr4C57BL/6J/?
Ebmgr1129S6/SvEvTac/Ebmgr1129S6/SvEvTac
Prf1tm1Sdz/Prf1tm1Sdz
involves: 129S6/SvEvTac * C57BL/6J 		abnormal response to transplant J:116666
Bmgr4C57BL/6J/?
Prf1tm1Sdz/Prf1tm1Sdz
involves: 129S6/SvEvTac * C57BL/6J 		abnormal response to transplant J:116666
Gzmatm1Simn/Gzmatm1Simn
Gzmbtm1Ley/Gzmbtm1Ley
Prf1tm1Sdz/Prf1tm1Sdz
B6.Cg-Gzmatm1Simn Gzmbtm1Ley Prf1tm1Sdz 		normal immune system phenotype J:92718
increased susceptibility to Flaviviridae infection J:90852
increased susceptibility to induced morbidity/mortality J:90852
increased susceptibility to parasitic infection J:81397
Ifngtm1Ts/Ifngtm1Ts
Prf1tm1Sdz/Prf1tm1Sdz
C.Cg-Prf1tm1Sdz Ifngtm1Ts 		abnormal tumor morphology J:77491
decreased tumor latency J:77491
increased B cell derived lymphoma incidence J:77491
increased lymphoma incidence J:77491
premature death J:77491
Ins2Akita/Ins2+
Prf1tm1Sdz/Prf1tm1Sdz
Rag1tm1Mom/Rag1tm1Mom
NOD.Cg-Rag1tm1Mom Ins2Akita Prf1tm1Sdz 		abnormal glucose homeostasis J:138005
abnormal pancreatic islet morphology J:138005
absent mature B cells J:138005
absent T cells J:138005
normal homeostasis/metabolism phenotype J:138005
hyperglycemia J:138005
increased erythrocyte cell number J:138005
increased granulocyte number J:138005
increased macrophage cell number J:138005
increased monocyte cell number J:138005
Ins2Akita/Ins2Akita
Prf1tm1Sdz/Prf1tm1Sdz
Rag1tm1Mom/Rag1tm1Mom
NOD.Cg-Rag1tm1Mom Ins2Akita Prf1tm1Sdz 		postnatal lethality, complete penetrance J:138005
Prf1tm1Clrk/Prf1tm1Clrk
Tg(INS-Il10)#Sar/0
involves: 129S7/SvEvBrd * BALB/c * NOD 		decreased susceptibility to autoimmune diabetes J:64051
Prf1tm1Sdz/Prf1tm1Sdz
Rag1tm1Mom/Rag1tm1Mom
NOD.Cg-Rag1tm1Mom Prf1tm1Sdz/SzJ 		abnormal response to transplant J:91764
increased circulating glucose level J:91764
Prf1tm1Sdz/Prf1tm1Sdz
X/Yaa
BXSB.B6-Prf1tm1Sdz/Dcr 		autoimmune response J:179430
premature death J:179430
Rag1tm1Mom/Rag1tm1Mom
Prf1tm1Sdz/Prf1tm1Sdz
NOD.Cg-Rag1tm1Mom Prf1tm1Sdz/Sz 		abnormal level of surface class II molecules J:109843
abnormal lymph node cortex morphology J:109843
abnormal response to transplant J:109843
abnormal spleen white pulp morphology J:109843
abnormal thymus cortex morphology J:109843
decreased CD4-positive, alpha-beta T cell number J:109843
decreased CD8-positive, alpha-beta T cell number J:109843
decreased immunoglobulin level J:109843
decreased mature B cell number J:109843
impaired natural killer cell mediated cytotoxicity J:109843
increased granulocyte number J:109843
increased immature B cell number J:109843
increased macrophage cell number J:109843
increased NK cell number J:109843
increased T cell derived lymphoma incidence J:109843
premature death J:109843
spleen hypoplasia J:109843
thymus hypoplasia J:109843
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory