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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Myh6
myosin, heavy polypeptide 6, cardiac muscle, alpha
MGI:97255
47 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background
Annotated Term Reference
Myh6tm1Jse/Myh6+
Tg(Myh6-TNNI3*G203S)1Chs/0
involves: 129X1/SvJ * C57BL/6
abnormal atrial thrombosis J:153302
abnormal cardiac muscle tissue morphology J:153302
abnormal heart echocardiography feature J:153302
abnormal myocardial fiber morphology J:153302
abnormal P wave J:153302
atrioventricular block J:153302
cardiac interstitial fibrosis J:153302
cardiac muscle necrosis J:153302
congestive heart failure J:153302
decreased cardiac muscle contractility J:153302
dilated cardiomyopathy J:153302
dilated heart J:153302
dilated heart atrium J:153302
enlarged myocardial fiber J:153302
increased heart weight J:153302
increased lung weight J:153302
irregular heartbeat J:153302
liver inflammation J:153302
liver vascular congestion J:153302
lung inflammation J:153302
myocardial fiber degeneration J:153302
postnatal lethality, complete penetrance J:153302
prolonged PR interval J:153302
prolonged QT interval J:153302
prolonged RR interval J:153302
pulmonary vascular congestion J:153302
Myh6tm1Jse/Myh6+
Postntm1Jmol/Postntm1Jmol
involves: 129S/SvEv * 129X1/SvJ
abnormal cardiovascular system physiology J:165269
cardiac fibrosis J:165269
decreased physiological sensitivity to xenobiotic J:165269
Myh6tm1Jse/Myh6+
Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol/0
Tg(Myh6-tTA)55Rbns/0
involves: 129X1/SvJ * FVB
abnormal cardiac muscle contractility J:234490
abnormal interventricular septum morphology J:234490
increased heart left ventricle size J:234490
increased heart weight J:234490
premature death J:234490
Plntm1Egk/Plntm1Egk
Tg(Myh6*)140Lnwd/0
involves: 129S2/SvPas * CBA * CF-1 * FVB/N
increased heart weight J:134706
Tg(Myh6*)1Lnwd/0
involves: C57BL/6 * FVB/N
abnormal cardiac thrombosis J:55938
abnormal coronary vessel morphology J:55938
abnormal heart echocardiography feature J:55938
abnormal heart morphology J:55938
abnormal myocardial fiber physiology J:55938
abnormal tricuspid valve morphology J:55938
decreased cardiac muscle relaxation J:55938
disorganized myocardium J:55938
heart left ventricle hypertrophy J:55938
thick mitral valve J:55938
thick ventricular wall J:55938
Tg(Myh6*)1Lnwd/Tg(Myh6*)1Lnwd
involves: C57BL/6 * FVB/N
abnormal cardiac thrombosis J:55938
abnormal coronary vessel morphology J:55938
abnormal heart echocardiography feature J:55938
abnormal heart morphology J:55938
heart left ventricle hypertrophy J:55938
increased heart weight J:55938
thick mitral valve J:55938
thick ventricular wall J:55938
Tg(Myh6*)131Lnwd/0
involves: C57BL/6 * CBA
abnormal heart morphology J:36522
cardiac hypertrophy J:31537
heart left ventricle hypertrophy J:31537
Tg(Myh6*)140Lnwd/0
involves: C57BL/6 * CBA
abnormal coronary vessel morphology J:31537, J:36522
abnormal vascular smooth muscle morphology J:31537, J:36522
cardiac hypertrophy J:31537, J:36522, J:134706
decreased cardiac muscle contractility J:134706
dilated heart left ventricle J:36522
heart left ventricle hypertrophy J:31537, J:36522, J:134706
impaired exercise endurance J:134706
increased heart weight J:134706
myocardial fiber degeneration J:36522
premature death J:134706
Tg(Myh6*)140Lnwd/0
Tg(Myh6-ADRBK1)27Wjk/0
involves: C57BL/6 * CBA * SJL
cardiac hypertrophy J:134706
Tg(Myh6*)140Lnwd/0
Tg(WTbeta2)4Wjk/0
involves: C57BL/6 * CBA
abnormal cardiac muscle contractility J:134706
cardiac hypertrophy J:134706
congestive heart failure J:134706
increased heart weight J:134706
premature death J:134706

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory