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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Mertk
MER proto-oncogene tyrosine kinase
MGI:96965
40 phenotypes from 4 alleles in 8 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Mertknmf12/Mertknmf12
C57BL/6J-Mertknmf12/J
abnormal retina morphology J:82238
decreased total retina thickness J:82238
Mertknmf12/Mertknmf12
involves: C57BL/6J
abnormal eye electrophysiology J:175587
abnormal retina photoreceptor layer morphology J:175587
abnormal retina pigmentation J:175587
abnormal tumor necrosis factor level J:175587
decreased retina photoreceptor cell number J:175587
increased retina apoptosis J:175587
retina photoreceptor degeneration J:175587
thin retina outer nuclear layer J:175587
Mertknmf12/Mertktm1Gkm
involves: 129P2/OlaHsd * C57BL/6J
abnormal retina morphology J:175587
decreased retina photoreceptor cell number J:175587
thin retina outer nuclear layer J:175587
Mertktm1Gkm/Mertktm1Gkm
B6.129P2-Mertktm1Gkm
decreased autoantibody level J:136377
decreased susceptibility to graft versus host disease J:136377
Mertktm1Gkm/Mertktm1Gkm
involves: 129P2/OlaHsd
abnormal cone electrophysiology J:81618
abnormal photoreceptor outer segment morphology J:81618
abnormal retina morphology J:81618
abnormal retina outer nuclear layer morphology J:81618
abnormal retina pigment epithelium morphology J:81618
abnormal retina vasculature morphology J:81618
abnormal rod electrophysiology J:81618
disorganized photoreceptor outer segment J:81618
photoreceptor outer segment degeneration J:81618
retina degeneration J:81618
retina pigment epithelium atrophy J:81618
retina rod cell degeneration J:81618
thin retina outer nuclear layer J:81618
Mertktm1Gkm/Mertktm1Gkm
involves: 129P2/OlaHsd * C57BL/6 * DBA/2
abnormal small intestine morphology J:53423
increased circulating tumor necrosis factor level J:53423
increased susceptibility to endotoxin shock J:53423
increased susceptibility to induced morbidity/mortality J:53423
increased tumor necrosis factor secretion J:53423
Mertktm1Gkm/Mertktm1Gkm
NOD.129P2-Mertktm1Gkm
abnormal mononuclear cell morphology J:147153
decreased susceptibility to autoimmune diabetes J:147153
decreased T cell number J:147153
increased T cell apoptosis J:147153
insulitis J:147153
Mertktm1Grl/Mertktm1Grl
involves: 129P2/OlaHsd
abnormal photoreceptor outer segment morphology J:116526
abnormal retina pigment epithelium morphology J:116526
blindness J:116526
normal cardiovascular system phenotype J:198769
decreased Sertoli cell phagocytosis J:133455
disorganized photoreceptor outer segment J:116526
enlarged spleen J:54681
retina photoreceptor degeneration J:116526
vagina atresia J:142166
Mertktm1Lex/Mertktm1Lex
involves: 129S5/SvEvBrd * C57BL/6
decreased platelet aggregation J:102333
decreased susceptibility to induced thrombosis J:102333

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory