78 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Ghrtm1Arge/Ghrtm1Arge Igf1tm1Arge/Igf1tm1Arge involves: 129S/SvEv * C57BL/6J * DBA * MF1	abnormal chondrocyte morphology	J:66913
	abnormal long bone epiphyseal plate proliferative zone	J:66913
	abnormal long bone hypertrophic chondrocyte zone	J:66913
	abnormal trabecular bone morphology	J:66913
	decreased width of hypertrophic chondrocyte zone	J:66913
	delayed endochondral bone ossification	J:66913
	postnatal growth retardation	J:66913
	proportional dwarf	J:66913
Gpc3tm1Arge/Gpc3tm1Arge Igf1tm1Arge/Igf1tm1Arge involves: 129S/SvEv * 129S1/Sv * C57BL/6J * DBA * MF1	perinatal lethality, incomplete penetrance	J:75054
	postnatal lethality, complete penetrance	J:75054
Gpc3tm1Arge/Y Igf1tm1Arge/Igf1tm1Arge involves: 129S/SvEv * 129S1/Sv * C57BL/6J * DBA * MF1	perinatal lethality, incomplete penetrance	J:75054
	postnatal lethality, complete penetrance	J:75054
Igf1tm1.1Dlr/Igf1tm1.1Dlr Tg(Ttr-IGF1)1Sykr/0 FVB.Cg-Igf1tm1.1Dlr Tg(Ttr-IGF1)1Sykr	abnormal branching of the mammary ductal tree	J:157350
	abnormal corpus luteum morphology	J:157350
	abnormal endometrial gland development	J:157350
	abnormal endometrium morphology	J:157350
	abnormal estrous cycle	J:157350
	abnormal insulin-like growth factor I level	J:157350
	abnormal mature ovarian follicle morphology	J:157350
	decreased birth body size	J:157350
	decreased circulating insulin level	J:157350
	decreased endometrial gland number	J:157350
	decreased gonadal fat pad weight	J:157350
	decreased litter size	J:157350
	decreased percent body fat/body weight	J:157350
	decreased total body fat amount	J:157350
	endometrium hypoplasia	J:157350
	normal homeostasis/metabolism phenotype	J:157350
	increased body length	J:157350
	increased circulating insulin-like growth factor I level	J:157350
	increased spleen weight	J:157350
	increased superovulation rate	J:157350
	normal mortality/aging	J:157350
	myometrium hypoplasia	J:157350
	ovary hypoplasia	J:157350
	prolonged diestrus	J:157350
	prolonged proestrus	J:157350
	reduced female fertility	J:157350
	short estrus	J:157350
Igf1tm1Arge/Igf1+ Liftm1Stw/Lif+ involves: 129S/SvEv * 129S1/Sv * C57BL/6 * MF1	increased growth hormone level	J:87585
Igf1tm1Arge/Igf1+ Liftm1Stw/Liftm1Stw involves: 129S/SvEv * 129S1/Sv	decreased motor neuron number	J:103711
Igf1tm1Arge/Igf1+ Liftm1Stw/Liftm1Stw involves: 129S/SvEv * 129S1/Sv * BALB/c * C57BL/6J * MF1	postnatal lethality	J:82113
Igf1tm1Arge/Igf1+ Liftm1Stw/Liftm1Stw involves: 129S/SvEv * 129S1/Sv * C57BL/6 * MF1	abnormal white fat cell morphology	J:87585
	decreased body mass index	J:87585
	decreased body weight	J:87585
	decreased gonadal fat pad weight	J:87585
	normal homeostasis/metabolism phenotype	J:87585
	increased circulating insulin-like growth factor I level	J:87585
	increased circulating leptin level	J:87585
	increased growth hormone level	J:87585
	slow postnatal weight gain	J:87585
Igf1tm1Arge/Igf1tm1Arge Igf1rtm1Arge/Igf1rtm1Arge either: (involves: 129S/SvEv) or (involves: 129S/SvEv * C57BL/6J) or (involves: 129S/SvEv * MF1)	decreased birth weight	J:15108
	delayed bone ossification	J:15108
	neonatal lethality, complete penetrance	J:15108
	respiratory failure	J:15108
Igf1tm1Arge/Igf1tm1Arge Igf2tm1Rob/Igf2+ either: (involves: 129S/SvEv) or (involves: 129S/SvEv * C57BL/6J) or (involves: 129S/SvEv * MF1)	decreased birth weight	J:15108
	delayed bone ossification	J:15108
	maternal imprinting	J:15108
	neonatal lethality, complete penetrance	J:15108
	respiratory failure	J:15108
	thin epidermis stratum spinosum	J:15108
Igf1tm1Arge/Igf1tm1Arge Liftm1Stw/Lif+ involves: 129S/SvEv * 129S1/Sv * BALB/c * C57BL/6J * MF1	delayed bone ossification	J:82113
	postnatal lethality	J:82113
Igf1tm1Arge/Igf1tm1Arge Liftm1Stw/Liftm1Stw involves: 129S/SvEv * 129S1/Sv	abnormal cerebellar Purkinje cell layer	J:103711
	decreased motor neuron number	J:103711
Igf1tm1Arge/Igf1tm1Arge Liftm1Stw/Liftm1Stw involves: 129S/SvEv * 129S1/Sv * BALB/c * C57BL/6J * MF1	abnormal keratinocyte morphology	J:82113
	abnormal long bone morphology	J:82113
	abnormal lung morphology	J:82113
	abnormal mitral cell morphology	J:82113
	abnormal olfactory bulb external plexiform layer morphology	J:82113
	abnormal olfactory bulb layer morphology	J:82113
	abnormal olfactory bulb mitral cell layer morphology	J:82113
	abnormal pulmonary alveolus morphology	J:82113
	abnormal skeleton morphology	J:82113
	abnormal type II pneumocyte morphology	J:82113
	absent type I pneumocytes	J:82113
	atelectasis	J:82113
	decreased body size	J:82113
	decreased body weight	J:82113
	decreased bone mineral density	J:82113
	delayed bone ossification	J:82113
	fragile skeleton	J:82113
	increased type II pneumocyte number	J:82113
	muscle hypoplasia	J:82113
	neonatal lethality, complete penetrance	J:82113
	thick pulmonary interalveolar septum	J:82113
	thin epidermis	J:82113
	underdeveloped hair follicles	J:82113
Igf1tm1Dlr/Igf1tm1Dlr Igfalstm1Yrb/Igfalstm1Yrb Tg(Alb1-cre)1Dlr/? involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N	abnormal femur morphology	J:79109
	abnormal limb bone morphology	J:79109
	abnormal long bone epiphyseal plate proliferative zone	J:79109
	decreased body length	J:79109
	decreased diameter of femur	J:79109
	decreased long bone epiphyseal plate size	J:79109
	decreased width of hypertrophic chondrocyte zone	J:79109
	short femur	J:79109