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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Hmgcr
3-hydroxy-3-methylglutaryl-Coenzyme A reductase
MGI:96159
32 phenotypes from 2 alleles in 1 genetic background
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Allelic Composition
Genetic Background
Annotated Term Reference
Hmgcrtm1Ishi/Hmgcr+
involves: 129S7/SvEvBrd * C57BL/6J
no abnormal phenotype detected J:86378
Hmgcrtm1Ishi/Hmgcrtm1Ishi
involves: 129S7/SvEvBrd * C57BL/6J
embryonic lethality, complete penetrance J:86378
Hmgcrtm2Ishi/Hmgcrtm2Ishi
involves: 129S7/SvEvBrd * C57BL/6J
no abnormal phenotype detected J:201488
Hmgcrtm2Ishi/Hmgcrtm2Ishi
Tg(Alb1-cre)1Dlr/0
involves: 129S7/SvEvBrd * C57BL/6J
abnormal circulating apolipoprotein level J:201488
abnormal circulating lipoprotein level J:201488
abnormal liver parenchyma morphology J:201488
abnormal liver physiology J:201488
decreased circulating cholesterol level J:201488
decreased circulating LDL cholesterol level J:201488
decreased circulating triglyceride level J:201488
decreased liver cholesterol level J:201488
enlarged liver J:201488
hepatic necrosis J:201488
hepatic steatosis J:201488
hypoglycemia J:201488
increased circulating alanine transaminase level J:201488
increased circulating aspartate transaminase level J:201488
increased circulating bilirubin level J:201488
increased circulating cholesterol level J:201488
increased circulating free fatty acid level J:201488
increased circulating LDL cholesterol level J:201488
increased circulating phospholipid level J:201488
increased collagen level J:201488
increased fatty acid level J:201488
increased liver triglyceride level J:201488
increased liver weight J:201488
increased unsaturated fatty acid level J:201488
jaundice J:201488
liver failure J:201488
pale liver J:201488
postnatal lethality, incomplete penetrance J:201488
premature death J:201488
weight loss J:201488

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/31/2020
MGI 6.15
The Jackson Laboratory