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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Hbegf
heparin-binding EGF-like growth factor
MGI:96070
44 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background
Annotated Term Reference
Btctm1Dcl/Btctm1Dcl
Hbegftm1Dcl/Hbegftm1Dcl
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
abnormal atrial thrombosis J:83820
abnormal atrioventricular valve morphology J:83820
abnormal semilunar valve morphology J:83820
cardiac fibrosis J:83820
decreased body weight J:83820
decreased ventricle muscle contractility J:83820
dilated heart left atrium J:83820
ectopic cartilage J:83820
enlarged aortic valve J:83820
enlarged pulmonary valve J:83820
premature death J:83820
Hprttm1(Ins2-HBEGF)Herr/Y
Tg(Gcg-HBEGF)#Herr/0
involves: 129 * C57BL/6
normal endocrine/exocrine gland phenotype J:159291
Phf24tm1.2(HBEGF)Azmo/Phf24tm1.2(HBEGF)Azmo
involves: 129 * BALB/cJ * C57BL/6
abnormal chemical nociception J:218052
abnormal mechanical nociception J:218052
normal behavior/neurological phenotype J:218052
decreased physiological sensitivity to xenobiotic J:218052
normal nervous system phenotype J:218052
Prkdcscid/Prkdcscid
Tg(INS-HBEGF*L148S*P149T)70Rin/0
C.BKa-Prkdcscid Tg(INS-HBEGF*L148S*P149T)70Rin
abnormal pancreatic islet morphology J:204420
decreased circulating insulin level J:204420
decreased pancreatic beta cell number J:204420
hyperglycemia J:204420
Siglechtm1.1Cln/Siglech+
Tg(CLEC4C-HBEGF)956Cln/0
involves: C57BL/6
decreased plasmacytoid dendritic cell number J:166504
Tg(CLEC4C-HBEGF)956Cln/0
C57BL/6-Tg(CLEC4C-HBEGF)956Cln
abnormal chemokine secretion J:166504
abnormal cytotoxic T cell physiology J:166504
abnormal NK cell physiology J:166504
abnormal NK T cell physiology J:166504
decreased CD8-positive, alpha-beta T cell number J:166504
decreased interferon-alpha secretion J:166504
decreased plasmacytoid dendritic cell number J:166504
decreased splenocyte number J:166504
impaired natural killer cell mediated cytotoxicity J:166504
increased interferon-gamma secretion J:166504
increased interleukin-12 secretion J:166504
increased susceptibility to Herpesvirales infection J:166504
small spleen J:166504
Tg(Ins2-HBEGF)5Rin/?
C57BL/6-Tg(Ins2-HBEGF)5Rin
abnormal pancreatic islet morphology J:204420
decreased circulating insulin level J:204420
decreased pancreatic beta cell number J:204420
hyperglycemia J:204420
increased urine glucose level J:204420
ketoaciduria J:204420
Tg(Myh6-HBEGF)#Iko/0
involves: C57BL/6 * DBA/2
abnormal atrial thrombosis J:93335
abnormal heart echocardiography feature J:93335
cardiac interstitial fibrosis J:93335
decreased cardiac muscle contractility J:93335
dilated cardiomyopathy J:93335
dilated heart J:93335
enlarged myocardial fiber J:93335
increased heart weight J:93335
myocardial fiber degeneration J:93335
premature death J:93335

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/23/2021
MGI 6.16
The Jackson Laboratory