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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Htt
huntingtin
MGI:96067
57 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Fan1em1Mem/Fan1em1Mem
Htttm5Mem/Htt+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal cell physiology J:298297
increased cellular sensitivity to alkylating agents J:298297
Fan1em1Mem/Fan1em1Mem
Htttm5Mem/Htt+
Mlh1tm1Rak/Mlh1tm1Rak
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J 		normal cellular phenotype J:298297
Fan1em2Mem/Fan1+
Htttm3Mem/Htt+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal cell physiology J:298297
Fan1em2Mem/Fan1em2Mem
Htttm3Mem/Htt+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal cell physiology J:298297
Fan1em2Mem/Fan1em2Mem
Htttm5Mem/Htt+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal cell physiology J:298297
Hap1tm1Id/Hap1+
Htttm1Szi/Htttm1Szi
involves: 129S/SvEv * 129S1/Sv * C57BL/6 		absent neural folds J:94581
absent somites J:94581
decreased embryo size J:94581
Hap1tm1Id/Hap1tm1Id
Htttm1Szi/Htttm1Szi
involves: 129S/SvEv * 129S1/Sv * C57BL/6 		absent neural folds J:94581
absent somites J:94581
decreased embryo size J:94581
Htttm1Hay/Htt+
Tg(YAC72)2511Hay/0
involves: FVB/N 		testicular atrophy J:67366
Htttm1Hay/Htttm1Hay
Tg(HTT*97Q)IXwy/0
Tg(YAC18)18Hay/Tg(YAC18)18Hay
FVB.Cg-Htttm1Hay Tg(HTT*97Q)IXwy Tg(YAC18)18Hay 		abnormal action potential J:215223
abnormal CNS synaptic transmission J:215223
abnormal corpus callosum morphology J:191147
abnormal depression-related behavior J:191147
abnormal forebrain morphology J:191147
abnormal motor capabilities/coordination/movement J:191147
abnormal motor learning J:191147
abnormal object recognition memory J:191147
abnormal striatum morphology J:191147
decreased excitatory postsynaptic current amplitude J:215223
decreased excitatory postsynaptic current frequency J:215223
decreased paired-pulse facilitation J:215223
impaired coordination J:191147
impaired spatial learning J:191147
impaired synaptic plasticity J:215223
increased body weight J:191147
increased stereotypic behavior J:191147
increased thigmotaxis J:191147
reduced long-term potentiation J:215223
Htttm1Hay/Htttm1Hay
Tg(YAC18)18Hay/0
involves: FVB/N 		normal mortality/aging J:67366
normal reproductive system phenotype J:67366
Htttm1Hay/Htttm1Hay
Tg(YAC46)668Hay/0
involves: FVB/N 		male infertility J:67366
normal mortality/aging J:67366
normal reproductive system phenotype J:67366
Htttm1Hay/Htttm1Hay
Tg(YAC72)2511Hay/0
involves: FVB/N 		abnormal male germ cell apoptosis J:67366
abnormal spermatid morphology J:67366
male infertility J:67366
normal mortality/aging J:67366
multinucleated giant male germ cells J:67366
oligozoospermia J:67366
normal reproductive system phenotype J:67366
testicular atrophy J:67366
Htttm1Hay/Htttm1Hay
Tg(YAC128)53Hay/0
involves: C57BL/6J * FVB 		normal mortality/aging J:120991
Htttm1Hay/Htttm1Hay
Tg(YAC353G6)W7Hay/0
involves: C57BL/6J * FVB/NJ 		normal mortality/aging J:120991
Htttm1Mfc/Htt+
Ppargc1atm1Dpk/Ppargc1a+
involves: 129S1/Sv * 129X1/SvJ 		abnormal striatum morphology J:116058
impaired coordination J:116058
neuron degeneration J:116058
Htttm1Msl/Htttm1Msl
involves: 129S1/Sv * C57BL/6J 		normal nervous system phenotype J:76018
Htttm1Szi/Htttm1Szi
Tg(HTT*)1Xwy/0
involves: 129S/SvEv * FVB 		normal mortality/aging J:157723
Htttm1Szi/Htttm1Szi
Tg(HTT*)BXwy/0
involves: 129S/SvEv * FVB 		normal mortality/aging J:157723
normal nervous system phenotype J:157723
Htttm2Msl/Htttm2Msl
involves: 129S1/Sv * C57BL/6J 		abnormal neuron physiology J:76018
abnormal striatum morphology J:79137
decreased locomotor activity J:79137
increased vertical activity J:79137
Htttm3Szi/Htt+
involves: 129S1/Sv 		increased exploration in new environment J:106763
Htttm3Szi/Htttm3Szi
involves: 129S1/Sv 		abnormal cell nucleus morphology J:106763
abnormal cell physiology J:106763
abnormal cell proliferation J:106763
decreased cell proliferation J:106763
enhanced coordination J:106763
increased exploration in new environment J:106763
normal mortality/aging J:106763
Htttm5Mem/Htt+
Msh2tm1Htr/Msh2tm1Htr
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * CD-1 * FVB/N 		neuronal intranuclear inclusions J:81666
Htttm5Mem/Htt+
Mtmr10em1Mem/Mtmr10em1Mem
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal cell physiology J:298297
Htttm5Mem/Htt+
Rrm2bem1Mem/Rrm2b+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		normal cellular phenotype J:298297
Htttm5Mem/Htt+
Ubr5em1Mem/Ubr5+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal cell physiology J:298297
Htttm5Mem/Htt+
Ubr5em2Mem/Ubr5em2Mem
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal cell physiology J:298297
Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-HTT*94Q,-lacZ)1Rhn/0
involves: C57BL/6 * CBA 		abnormal dorsal striatum morphology J:61490
astrocytosis J:61490
decreased brain size J:61490
decreased grooming behavior J:61490
decreased locomotor activity J:61490
decreased striatum size J:61490
dystonia J:61490
enlarged brain ventricles J:61490
gliosis J:61490
limb grasping J:61490
neuronal intranuclear inclusions J:61490
premature death J:61490
prenatal lethality, incomplete penetrance J:61490
tremors J:61490
Tg(tetO-HTT*94Q,-lacZ)1Rhn/0
involves: C57BL/6 * CBA 		no abnormal phenotype detected J:61490
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory