Fan1^em1Mem
Endonuclease-mediated Allele Detail

Summary

• Symbol: Fan1^em1Mem
• Name: FANCD2/FANCI-associated nuclease 1; endonuclease-mediated mutation 1, Marcy E MacDonald
• MGI ID: MGI:6489290
• Synonyms: Fan1_del10
• Gene: Fan1 Location: Chr7:63996506-64023843 bp, - strand Genetic Position: Chr7, 34.64 cM
• Alliance: Fan1^em1Mem page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR-targeting induced a 10 bp deletion. (J:298297)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fan1 Mutation: 98 strains or lines available

References

• Original: J:298297 Loupe JM, et al., Promotion of somatic CAG repeat expansion by Fan1 knock-out in Huntington's disease knock-in mice is blocked by Mlh1 knock-out. Hum Mol Genet. 2020 Nov 4;29(18):3044-3053
• All: 1 reference(s)