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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Slc6a1
solute carrier family 6 (neurotransmitter transporter, GABA), member 1
MGI:95627
30 phenotypes from 3 alleles in 3 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Slc6a1tm1.1Lst/Slc6a1tm1.1Lst
involves: 129S1/Sv
no abnormal phenotype detected J:80438
Slc6a1tm1Lst/Slc6a1tm1Lst
involves: 129S1/Sv * C57BL/6
abnormal inhibitory postsynaptic currents J:95639
abnormal neurotransmitter secretion J:95639
abnormal neurotransmitter uptake J:95639
Slc6a1tm1Mlit/Slc6a1+
involves: 129S1/Sv * C57BL/6
abnormal bitter taste sensitivity J:144919
abnormal conditioned taste aversion behavior J:144919
abnormal contextual conditioning behavior J:144919
alcohol preference J:144919
decreased locomotor activity J:144919
hyperactivity elicited by ethanol administration J:144919
increased alcohol consumption J:144919
saccharin preference J:144919
Slc6a1tm1Mlit/Slc6a1tm1Mlit
B6.129S1-Slc6a1tm1Mlit
abnormal GABA-mediated receptor currents J:204368
abnormal latent inhibition of conditioning behavior J:204368
abnormal object recognition memory J:204368
abnormal response to novel object J:204368
abnormal social/conspecific interaction behavior J:204368
decreased prepulse inhibition J:204368
enhanced behavioral response to xenobiotic J:204368
impaired cued conditioning behavior J:204368
impaired spatial working memory J:204368
increased locomotor activity J:204368
normal nervous system phenotype J:204368
reduced sensorimotor gating J:204368
Slc6a1tm1Mlit/Slc6a1tm1Mlit
involves: 129S1/Sv * C57BL/6
abnormal behavioral response to xenobiotic J:144919
abnormal bitter taste sensitivity J:144919
abnormal conditioned taste aversion behavior J:144919
ataxia J:144919
decreased body weight J:144919
hyperactivity J:144919
increased startle reflex J:144919
tremors J:144919

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/30/2024
MGI 6.23
The Jackson Laboratory