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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Sgca
sarcoglycan, alpha (dystrophin-associated glycoprotein)
MGI:894698
24 phenotypes from 4 alleles in 6 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Sgcatm1Eeng/Sgcatm1Eeng
involves: 129S/SvEv * 129X1/SvJ
impaired skeletal muscle contractility J:83034
Sgcatm1Isrd/Sgcatm1Isrd
involves: 129S2/SvPas * BALB/c * C57BL/6
normal muscle phenotype J:133929
Sgcatm1Kcam/Sgcatm1Kcam
involves: 129S1/Sv * 129X1/SvJ
abnormal circulating pyruvate kinase level J:49992
abnormal muscle contractility J:49992
abnormal muscle fiber morphology J:49992
abnormal sarcolemma morphology J:49992
abnormal skeletal muscle fiber morphology J:133929
calcified muscle J:49992
cardiac fibrosis J:177563
cardiac muscle necrosis J:177563
cardiomyopathy J:177563
centrally nucleated skeletal muscle fibers J:49992
dystrophic muscle J:49992
heart inflammation J:177563
increased circulating creatine kinase level J:49992, J:130252
increased extensor digitorum longus weight J:49992
increased soleus weight J:49992
normal muscle phenotype J:177563
Sgcatm2Kcam/Sgcatm2Kcam
B6.129S6-Sgcatm2Kcam/J
abnormal muscle physiology J:250485
abnormal skeletal muscle morphology J:250485
decreased grip strength J:250485
decreased pulmonary respiratory rate J:250485
dystrophic muscle J:250485
increased circulating creatine kinase level J:250485
skeletal muscle fibrosis J:250485
Sgcatm2Kcam/Sgcatm2Kcam
either: (129S6/SvEvTac-Sgcatm2Kcam) or (involves: 129S6/SvEvTac * C57BL/6J)
abnormal muscle contractility J:130252
abnormal muscle fiber morphology J:130252
abnormal sarcolemma morphology J:130252
calcified muscle J:130252
dystrophic muscle J:130252
increased circulating creatine kinase level J:130252
increased muscle weight J:130252
Sgcatm2Kcam/Sgcatm2Kcam
Tg(Ckmm-cre)5Khn/0
either: (involves: 129S4/SvJae * 129S6/SvEvTac * FVB) or (involves: 129S6/SvEvTac * C57BL/6J * FVB)
normal homeostasis/metabolism phenotype J:130252
normal muscle phenotype J:130252

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory