Dok1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Dok1
docking protein 1
MGI:893587

19 phenotypes from 2 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Dok1^tm1Ppp/Dok1^tm1Ppp 129S1/Sv-Dok1^tm1Ppp	abnormal bone marrow cell morphology/development	J:95640
	abnormal T cell proliferation	J:95640
	increased fibroblast proliferation	J:95640
	increased lung adenocarcinoma incidence	J:158011
Dok1^tm1Yyam/Dok1^tm1Yyam B6.129S4-Dok1^tm1Yyam	decreased body weight	J:133566
	decreased brown adipose tissue mass	J:133566
	decreased circulating insulin level	J:133566
	decreased circulating leptin level	J:133566
	decreased epididymal fat pad weight	J:133566
	decreased fat cell size	J:133566
	decreased inguinal fat pad weight	J:133566
	decreased percent body fat/body weight	J:133566
	decreased susceptibility to weight gain	J:133566
	improved glucose tolerance	J:133566
	increased circulating adiponectin level	J:133566
	increased insulin sensitivity	J:133566
	increased oxygen consumption	J:133566
Dok1^tm1Yyam/Dok1^tm1Yyam involves: 129S4/SvJae * C57BL/6	decreased IgM level	J:95641
Dok1^tm1Yyam/Dok1^tm1Yyam involves: 129S4/SvJae * C57BL/6	increased B cell proliferation	J:95641

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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