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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Cftr
cystic fibrosis transmembrane conductance regulator
MGI:88388
33 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cfmq1129X1/SvJ/Cfmq1C57BL/6J
Cftrtm1Unc/Cftrtm1Unc
involves: 129X1/SvJ * C57BL/6J 		abnormal crypts of Lieberkuhn morphology J:101842
decreased body weight J:101842
intestinal inflammation J:101842
normal mortality/aging J:101842
Cfmq2129X1/SvJ/Cfmq2129X1/SvJ
Cftrtm1Unc/Cftrtm1Unc
involves: 129X1/SvJ * C57BL/6J 		abnormal crypts of Lieberkuhn morphology J:101842
decreased body weight J:101842
intestinal inflammation J:101842
normal mortality/aging J:101842
Cfmq3129X1/SvJ/Cfmq3C57BL/6J
Cftrtm1Unc/Cftrtm1Unc
involves: 129X1/SvJ * C57BL/6J 		abnormal crypts of Lieberkuhn morphology J:101842
decreased body weight J:101842
intestinal inflammation J:101842
normal mortality/aging J:101842
Cftrtm1Bay/Cftrtm1Bay
involves: 129S7/SvEvBrd * C57BL/6J 		abnormal colon morphology J:15244
abnormal gland morphology J:15244
abnormal intestinal goblet cell morphology J:15244
abnormal intestine morphology J:15244
acute pancreas inflammation J:15244
aphagia J:15244
cachexia J:15244
crypts of Lieberkuhn abscesses J:15244
decreased intestinal epithelial chloride transmembrane transport J:15244
decreased respiratory epithelial chloride transmembrane transport J:15244
dilated crypt of Lieberkuhn J:15244
distended abdomen J:15244
enlarged gallbladder J:15244
intestinal mucus accumulation J:15244
intestinal obstruction J:15244
intestinal ulcer J:15244
lacrimal gland atrophy J:15244
pancreatic acinar cell atrophy J:15244
postnatal growth retardation J:15244
postnatal lethality, incomplete penetrance J:15244
weight loss J:15244
Cftrtm1Eur/Cftrtm1Eur
Nherf1tm1Ssl/Nherf1tm1Ssl
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ 		abnormal physiological response to xenobiotic J:128912
Cftrtm1Unc/Cftr+
Tmrdq1BALB/cJ/Tmrdq1BALB/cJ
involves: BALB/cJ * C57BL/6J 		transmission ratio distortion J:125558
Cftrtm1Unc/Cftrtm1Unc
Tg(FABPCFTR)1Jaw/0
involves: 129P2/OlaHsd * C57BL/6 * FVB/N 		abnormal alveolar macrophage physiology J:129519
abnormal cecum morphology J:21934
abnormal colon goblet cell morphology J:21934
decreased intestinal epithelial chloride transmembrane transport J:21934
normal mortality/aging J:21934
Cftrtm1Unc/Cftrtm1Unc
Tg(FABPCFTR)1Jaw/0
Tg(Scgb1a1-Scnn1b)6608Bouc/0
involves: 129P2/OlaHsd * C3H * C57BL/6 * FVB/N 		abnormal mucociliary clearance J:191673
postnatal lethality, incomplete penetrance J:191673
pulmonary epithelial necrosis J:191673
respiratory system inflammation J:191673
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory