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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Cd28
CD28 antigen
MGI:88327
55 phenotypes from 8 alleles in 15 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cd28tm1.1Huen/Cd28tm1.1Huen
Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
involves: C57BL/6 * C57BL/6NTac 		abnormal regulatory T cell physiology J:191101
decreased regulatory T cell number J:191101
Cd28tm1a(EUCOMM)Hmgu/Cd28tm1a(EUCOMM)Hmgu
C57BL/6N-Cd28tm1a(EUCOMM)Hmgu/H 		decreased T cell number J:165965
increased CD4-positive, alpha-beta T cell number J:165965
increased leukocyte cell number J:165965
Cd28tm1Jmg/Cd28tm1Jmg
B6.129X1-Cd28tm1Jmg 		decreased interleukin-2 secretion J:149888
decreased susceptibility to experimental autoimmune encephalomyelitis J:149888
increased susceptibility to type I hypersensitivity reaction J:149888
Cd28tm1Jmg/Cd28tm1Jmg
involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 		abnormal cytokine secretion J:124570
abnormal germinal center B cell physiology J:124570
abnormal lymphopoiesis J:124570
decreased immunoglobulin level J:124570
decreased interleukin-2 secretion J:124570
Cd28tm1Jmg/Cd28tm1Mak
involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 		abnormal cytokine secretion J:124570
abnormal germinal center B cell physiology J:124570
abnormal lymphopoiesis J:124570
decreased immunoglobulin level J:124570
decreased interleukin-2 secretion J:124570
decreased T cell proliferation J:124570, J:149888
Cd28tm1Ltu/Cd28tm1Ltu
Foxp3tm4(YFP/icre)Ayr/Foxp3+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal eyelid morphology J:194503
decreased locomotor activity J:194503
decreased regulatory T cell number J:194503
decreased T cell proliferation J:194503
enlarged lymph nodes J:194503
enlarged spleen J:194503
focal hair loss J:194503
hunched posture J:194503
increased activated T cell number J:194503
increased B cell number J:194503
increased susceptibility to autoimmune disorder J:194503
increased susceptibility to experimental autoimmune encephalomyelitis J:194503
ruffled hair J:194503
skin inflammation J:194503
skin lesions J:194503
Cd28tm1Mak/Cd28tm1Mak
B6.129S2-Cd28tm1Mak 		abnormal cytotoxic T cell physiology J:76373
Cd28tm1Mak/Cd28tm1Mak
B6.129S2-Cd28tm1Mak/J 		brain inflammation J:57613
decreased susceptibility to experimental autoimmune encephalomyelitis J:57613
Cd28tm1Mak/Cd28tm1Mak
involves: 129S2/SvPas 		abnormal class switch recombination J:123989
abnormal regulatory T cell physiology J:191101
decreased interferon-gamma secretion J:205441
decreased interleukin-2 secretion J:130882, J:205441
decreased regulatory T cell number J:191101, J:205441
decreased spleen germinal center number J:123989
decreased T cell proliferation J:123989, J:130882, J:205441
enlarged thymus J:205441
Cd28tm1Mak/Cd28tm1Mak
involves: 129S2/SvPas * C57BL/6 		abnormal NK cell physiology J:95353
decreased circulating interferon-gamma level J:95353
decreased circulating interleukin-4 level J:95353
decreased interleukin-2 secretion J:149888
decreased susceptibility to experimental autoimmune encephalomyelitis J:149888
decreased T cell proliferation J:149888
increased susceptibility to type I hypersensitivity reaction J:149888
increased T cell apoptosis J:149888
Cd28tm1Mak/Cd28tm1Mak
involves: 129S2/SvPas * C57BL/6 * DBA/2 		abnormal CD4-positive, alpha-beta T cell physiology J:14194
abnormal class switch recombination J:14194
decreased IgG1 level J:14194
decreased IgG2b level J:14194
decreased immunoglobulin level J:14194
decreased interleukin-2 secretion J:14194
decreased T cell proliferation J:14194
increased IgG2a level J:14194
Cd28tm1Mak/Cd28tm1Mak
involves: 129S2/SvPas * NOD 		abnormal T-helper 1 physiology J:35353
abnormal T-helper 2 physiology J:35353
decreased IgG2a level J:35353
decreased interleukin-2 secretion J:35353
decreased interleukin-4 secretion J:35353
decreased T cell proliferation J:35353
increased interferon-gamma secretion J:35353
increased susceptibility to autoimmune diabetes J:35353
Cd28tm1Mak/Cd28tm1Mak
NOD.129S2-Cd28tm1Mak 		abnormal CD4-positive, alpha-beta T cell physiology J:61905
abnormal response to transplant J:61905
increased susceptibility to autoimmune diabetes J:93421
increased T cell proliferation J:93421
Cd28tm1Pjl/Cd28tm1Pjl
involves: 129P2/OlaHsd * C57BL/6 		abnormal class switch recombination J:83722
abnormal cytotoxic T cell physiology J:83722
abnormal immunoglobulin level J:83722
decreased IgG1 level J:83722
decreased IgG2a level J:83722
decreased IgM level J:83722
decreased interleukin-12 secretion J:83722
decreased susceptibility to type IV hypersensitivity reaction J:83722
increased splenocyte proliferation J:83722
Cd28tm1Shr/Cd28tm1Shr
involves: 129S4/SvJae * BALB/c * C57BL/6 		decreased CD4-positive, alpha-beta T cell number J:68642
decreased interleukin-2 secretion J:68642
decreased T cell proliferation J:68642
Cd28tm2.1Jmg/Cd28tm2.1Jmg
B6.129X1-Cd28tm2.1Jmg 		no abnormal phenotype detected J:149888
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory