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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Apex1
apurinic/apyrimidinic endonuclease 1
MGI:88042
33 phenotypes from 4 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Apex1tm1Cur/Apex1+
involves: 129S1/Sv
abnormal nitric oxide homeostasis J:102294
abnormal response/metabolism to endogenous compounds J:102294
abnormal vascular smooth muscle physiology J:119957
abnormal vascular wound healing J:119957
decreased vasoconstriction J:102294
decreased vasodilation J:102294
increased circulating interleukin-1 alpha level J:119957
increased circulating interleukin-10 level J:119957
increased mean systemic arterial blood pressure J:102294
increased vasoconstriction J:102294
Apex1tm1Cur/Apex1tm1Cur
involves: 129S1/Sv * C57BL/6J
abnormal embryo development J:34891
embryonic lethality between implantation and somite formation, complete penetrance J:34891
Apex1tm1Djc/Apex1+
involves: 129X1/SvJ * NTac:NIHS
abnormal liver morphology J:92957
abnormal seminiferous tubule morphology J:92957
Apex1tm1Djc/Apex1tm1Djc
involves: 129X1/SvJ * NTac:NIHS
abnormal embryo development J:50702
abnormal embryonic epiblast morphology J:50702
abnormal visceral yolk sac morphology J:50702
embryonic growth retardation J:50702
embryonic lethality during organogenesis, complete penetrance J:50702
increased cellular sensitivity to gamma-irradiation J:50702
increased embryonic epiblast cell apoptosis J:50702
Apex1tm1Ecf/Apex1+
either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6)
abnormal cell death J:70397
cardiac fibrosis J:70397
decreased cellular sensitivity to ultraviolet irradiation J:70397
heart inflammation J:70397
increased carcinoma incidence J:70397
increased cellular sensitivity to oxidative stress J:70397
increased lymphoma incidence J:70397
increased sarcoma incidence J:70397
increased tumor incidence J:70397
myocarditis J:70397
pericarditis J:70397
prenatal lethality, incomplete penetrance J:70397
Apex1tm1Ecf/Apex1tm1Ecf
either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6)
embryonic lethality between implantation and somite formation, complete penetrance J:70397
Apex1tm2Cur/Apex1tm2Cur
involves: 129S1/Sv
no abnormal phenotype detected J:83750

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/12/2019
MGI 6.14
The Jackson Laboratory