Chrne Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Chrne
cholinergic receptor, nicotinic, epsilon polypeptide
MGI:87894

21 phenotypes from 4 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Chrne^m1Btlr/Chrne^m1Btlr C57BL/6J-Chrne^m1Btlr	decreased body weight	J:216046
Chrne^m1Btlr/Chrne^m1Btlr C57BL/6J-Chrne^m1Btlr	premature death	J:216046
Chrne^tm1Jrs/Chrne^tm1Jrs involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal motor nerve collateral sprouting	J:74958
	abnormal neuromuscular synapse morphology	J:74958
	decreased locomotor activity	J:74958
	premature death	J:74958
	skeletal muscle atrophy	J:74958
	slow postnatal weight gain	J:74958
	weakness	J:74958
Chrne^tm1Vwi/Chrne^tm1Vwi involves: 129P2/OlaHsd * C57BL/6	abnormal miniature endplate potential	J:36557
	abnormal neuromuscular synapse morphology	J:36557
	abnormal PNS synaptic transmission	J:36557
	abnormal skeletal muscle morphology	J:36557
	decreased body weight	J:36557
	decreased grip strength	J:36557
	decreased muscle weight	J:36557
	impaired skeletal muscle contractility	J:36557
	premature death	J:36557
	skeletal muscle atrophy	J:36557
	weakness	J:36557
Tg(Ckm-Chrne*L269F)5Cgz/? involves: FVB/NJ	abnormal action potential	J:193524
	abnormal endplate potential	J:193524
	abnormal miniature endplate potential	J:193524
	abnormal neuromuscular synapse morphology	J:193524
	abnormal PNS synaptic transmission	J:193524
	abnormal skeletal muscle fiber morphology	J:193524
	decreased locomotor activity	J:193524
	increased physiological sensitivity to xenobiotic	J:193524
	increased pulmonary respiratory rate	J:193524
	muscle weakness	J:193524
	skeletal muscle fiber degeneration	J:193524

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/30/2024 MGI 6.23