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Chrnetm1Vwi
Targeted Allele Detail
Summary
Symbol: Chrnetm1Vwi
Name: cholinergic receptor, nicotinic, epsilon polypeptide; targeted mutation 1, Veit Witzemann
MGI ID: MGI:2158741
Synonyms: AChRepsilon -
Gene: Chrne  Location: Chr11:70505709-70510042 bp, - strand  Genetic Position: Chr11, 43.14 cM
Alliance: Chrnetm1Vwi page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:36557
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA genomic fragment containing part of exon 7 and exon 8 was replaced with a neomycin selection cassette. These sequences encode essential regions for the function of the protien. RT-PCR experiments on RNA derived from muscle tissue of homozygous mice demonstrated that no detectable levels of wild-type transcript were produced from this allele. (J:36557)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Chrne Mutation:  22 strains or lines available
References
Original:  J:36557 Witzemann V, et al., Acetylcholine receptor epsilon-subunit deletion causes muscle weakness and atrophy in juvenile and adult mice. Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):13286-91
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/02/2024
MGI 6.23
The Jackson Laboratory