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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Fan1
FANCD2/FANCI-associated nuclease 1
MGI:3045266
22 phenotypes from 5 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Fan1em1Mem/Fan1em1Mem
C57BL/6J-Fan1em1Mem
abnormal cell nucleus morphology J:298297
increased cellular sensitivity to alkylating agents J:298297
Fan1em2Mem/Fan1em2Mem
C57BL/6J-Fan1em2Mem
abnormal cell nucleus morphology J:298297
increased cellular sensitivity to alkylating agents J:298297
Fan1tm1.1Jrou/Fan1tm1.1Jrou
involves: 129P2/OlaHsd
abnormal DNA repair J:232403
abnormal renal tubule epithelium morphology J:232403
abnormal renal tubule morphology J:232403
dilated renal tubule J:232403
increased physiological sensitivity to xenobiotic J:232403
polyploidy J:232403
renal tubule atrophy J:232403
normal renal/urinary system phenotype J:232403
Fan1tm1a(KOMP)Wtsi/Fan1tm1a(KOMP)Wtsi
129S1.B6-Fan1tm1a(KOMP)Wtsi
cachexia J:242198
dehydration J:242198
increased blood urea nitrogen level J:242198
increased kidney cell proliferation J:242198
increased physiological sensitivity to xenobiotic J:242198
increased sensitivity to induced cell death J:242198
increased susceptibility to xenobiotic induced morbidity/mortality J:242198
renal interstitial fibrosis J:242198
normal renal/urinary system phenotype J:242198
tubulointerstitial nephritis J:242198
Fan1tm1d(KOMP)Wtsi/Fan1tm1d(KOMP)Wtsi
involves: C57BL/6N * FVB/N
abnormal cell nucleus morphology J:232402
abnormal hematopoietic stem cell physiology J:232402
abnormal renal tubule morphology J:232402
decreased liver function J:232402
normal hematopoietic system phenotype J:232402
increased hepatocyte karyomegaly J:232402
increased physiological sensitivity to xenobiotic J:232402
increased susceptibility to xenobiotic induced morbidity/mortality J:232402
polyploidy J:232402
normal renal/urinary system phenotype J:232402

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/30/2024
MGI 6.23
The Jackson Laboratory