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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Nlrc4
NLR family, CARD domain containing 4
MGI:3036243
27 phenotypes from 9 alleles in 8 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Nlrc4em1Vnce/Nlrc4em1Vnce
C57BL/6-Nlrc4em1Vnce
decreased inflammatory response J:294930
decreased lactate dehydrogenase level J:294930
increased susceptibility to bacterial infection induced morbidity/mortality J:294930
normal mortality/aging J:294930
normal reproductive system phenotype J:294930
Nlrc4em2Vnce/Nlrc4em2Vnce
C57BL/6-Nlrc4em2Vnce
decreased inflammatory response J:294930
decreased lactate dehydrogenase level J:294930
normal mortality/aging J:294930
normal reproductive system phenotype J:294930
Nlrc4em3Vnce/Nlrc4em3Vnce
C57BL/6-Nlrc4em3Vnce
normal homeostasis/metabolism phenotype J:294930
normal immune system phenotype J:294930
normal mortality/aging J:294930
normal reproductive system phenotype J:294930
Nlrc4m1Btlr/Nlrc4+
C57BL/6J-Nlrc4m1Btlr
decreased interleukin-1 beta secretion J:225933
Nlrc4m1Btlr/Nlrc4m1Btlr
C57BL/6J-Nlrc4m1Btlr
decreased interleukin-1 beta secretion J:225933
Nlrc4tm1Gln/Nlrc4tm1Gln
involves: 129S5/SvEvBrd
normal immune system phenotype J:173245
Nlrc4tm1Gne/Nlrc4tm1Gne
involves: C57BL/6N
normal immune system phenotype J:189256
Nlrc4tm1Nnz/Nlrc4tm1Nnz
involves: 129 * C57BL/6J
abnormal macrophage physiology J:112671, J:117251
increased susceptibility to bacterial infection J:117251
Nlrc4tm1Vmd/Nlrc4tm1Vmd
C57BL/6N-Nlrc4tm1Vmd
abnormal cell death J:91292
decreased interleukin-1 beta secretion J:91292
Nlrc4tm1Vmd/Nlrc4tm1Vmd
involves: C57BL/6N
abnormal cytokine secretion J:106976
abnormal response to infection J:106976
Tg(Cd74-Nlrc4*)1Kyas/0
involves: C57BL/6N
abnormal spleen morphology J:219652
arthritis J:219652
dermatitis J:219652
enlarged spleen J:219652
increased circulating interleukin-1 beta level J:219652
increased circulating interleukin-17 level J:219652
increased inflammatory response J:219652
increased interleukin-1 beta secretion J:219652
increased neutrophil cell number J:219652
increased splenocyte number J:219652
increased T cell number J:219652
joint inflammation J:219652
joint swelling J:219652
skin inflammation J:219652

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/30/2021
MGI 6.17
The Jackson Laboratory