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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Lzts1
leucine zipper, putative tumor suppressor 1
MGI:2684762
24 phenotypes from 2 alleles in 2 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Lzts1tm1Cro/Lzts1+
involves: 129 * C57BL/6J
increased carcinoma incidence J:119989
increased gastric adenocarcinoma incidence J:119989
increased hepatocellular carcinoma incidence J:119989
increased lung adenoma incidence J:119989
increased lymphoma incidence J:119989
increased mammary gland tumor incidence J:119989
increased stomach tumor incidence J:119989
increased tumor incidence J:119989
Lzts1tm1Cro/Lzts1tm1Cro
involves: 129 * C57BL/6J
abnormal cell cycle J:119989
abnormal cell physiology J:119989
decreased fibroblast proliferation J:119989
increased carcinoma incidence J:119989
increased fibroblast apoptosis J:119989
increased gastric adenocarcinoma incidence J:119989
increased hepatocellular carcinoma incidence J:119989
increased lung adenocarcinoma incidence J:119989
increased lymphoma incidence J:119989
increased mammary gland tumor incidence J:119989
increased sarcoma incidence J:119989
increased stomach tumor incidence J:119989
increased tumor incidence J:119989
Lzts1tm1Kso/Lzts1tm1Kso
B6J.B6NTac-Lzts1tm1Kso
abnormal CNS synapse formation J:226686
abnormal CNS synaptic transmission J:226686
abnormal dendritic spine morphology J:226686
abnormal glutamate-mediated receptor currents J:226686
abnormal miniature excitatory postsynaptic currents J:226686
abnormal object recognition memory J:226686
abnormal spatial working memory J:226686
normal behavior/neurological phenotype J:226686
increased anxiety-related response J:226686
increased tumor incidence J:226686
prolonged excitatory postsynaptic current decay time J:226686

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory