About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Lzts1
leucine zipper, putative tumor suppressor 1
MGI:2684762
24 phenotypes from 2 alleles in 2 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background
Annotated Term Reference
Lzts1tm1Cro/Lzts1+
involves: 129 * C57BL/6J
increased carcinoma incidence J:119989
increased gastric adenocarcinoma incidence J:119989
increased hepatocellular carcinoma incidence J:119989
increased lung adenoma incidence J:119989
increased lymphoma incidence J:119989
increased mammary gland tumor incidence J:119989
increased stomach tumor incidence J:119989
increased tumor incidence J:119989
Lzts1tm1Cro/Lzts1tm1Cro
involves: 129 * C57BL/6J
abnormal cell cycle J:119989
abnormal fibroblast physiology J:119989
decreased fibroblast proliferation J:119989
increased carcinoma incidence J:119989
increased fibroblast apoptosis J:119989
increased gastric adenocarcinoma incidence J:119989
increased hepatocellular carcinoma incidence J:119989
increased lung adenocarcinoma incidence J:119989
increased lymphoma incidence J:119989
increased mammary gland tumor incidence J:119989
increased sarcoma incidence J:119989
increased stomach tumor incidence J:119989
increased tumor incidence J:119989
Lzts1tm1Kso/Lzts1tm1Kso
B6J.B6NTac-Lzts1tm1Kso
abnormal CNS synapse formation J:226686
abnormal CNS synaptic transmission J:226686
abnormal dendritic spine morphology J:226686
abnormal glutamate-mediated receptor currents J:226686
abnormal miniature excitatory postsynaptic currents J:226686
abnormal object recognition memory J:226686
abnormal spatial working memory J:226686
normal behavior/neurological phenotype J:226686
increased anxiety-related response J:226686
increased tumor incidence J:226686
prolonged excitatory postsynaptic current decay time J:226686

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
04/23/2024
MGI 6.23
The Jackson Laboratory